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Biochemical analysis of leishmanial and human GDP-Mannose Pyrophosphorylases and selection of inhibitors as new leads
Leishmaniases are an ensemble of diseases caused by the protozoan parasite of the genus Leishmania. Current antileishmanial treatments are limited and present main issues of toxicity and drug resistance emergence. Therefore, the generation of new inhibitors specifically directed against a leishmania...
Autores principales: | Mao, Wei, Daligaux, Pierre, Lazar, Noureddine, Ha-Duong, Tâp, Cavé, Christian, van Tilbeurgh, Herman, Loiseau, Philippe M., Pomel, Sébastien |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429698/ https://www.ncbi.nlm.nih.gov/pubmed/28389670 http://dx.doi.org/10.1038/s41598-017-00848-8 |
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