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Frequent GU wobble pairings reduce translation efficiency in Plasmodium falciparum

Plasmodium falciparum genome has 81% A+T content. This nucleotide bias leads to extreme codon usage bias and culminates in frequent insertion of asparagine homorepeats in the proteome. Using recodonized GFP sequences, we show that codons decoded via G:U wobble pairing are suboptimal codons that are...

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Detalles Bibliográficos
Autores principales:	Chan, Sherwin, Ch’ng, Jun-Hong, Wahlgren, Mats, Thutkawkorapin, Jessada
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429705/ https://www.ncbi.nlm.nih.gov/pubmed/28389662 http://dx.doi.org/10.1038/s41598-017-00801-9

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