TGF-β induces phosphorylation of phosphatase and tensin homolog: implications for fibrosis of the trabecular meshwork tissue in glaucoma

Fundamental cell signaling mechanisms that regulate dynamic remodeling of the extracellular matrix (ECM) in mechanically loaded tissues are not yet clearly understood. Trabecular meshwork (TM) tissue in the eye is under constant mechanical stress and continuous remodeling of ECM is crucial to mainta...

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Detalles Bibliográficos
Autores principales: Tellios, Nikoleta, Belrose, Jillian C., Tokarewicz, Alexander C., Hutnik, Cindy, Liu, Hong, Leask, Andrew, Motolko, Michael, Iijima, Miho, Parapuram, Sunil K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429747/
https://www.ncbi.nlm.nih.gov/pubmed/28400560
http://dx.doi.org/10.1038/s41598-017-00845-x

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