A hybrid stochastic model of folate-mediated one-carbon metabolism: Effect of the common C677T MTHFR variant on de novo thymidylate biosynthesis

Folate-mediated one-carbon metabolism (FOCM) is an interconnected network of metabolic pathways, including those required for the de novo synthesis of dTMP and purine nucleotides and for remethylation of homocysteine to methionine. Mouse models of folate-responsive neural tube defects (NTDs) indicat...

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Detalles Bibliográficos
Autores principales: Misselbeck, Karla, Marchetti, Luca, Field, Martha S., Scotti, Marco, Priami, Corrado, Stover, Patrick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429759/
https://www.ncbi.nlm.nih.gov/pubmed/28400561
http://dx.doi.org/10.1038/s41598-017-00854-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429759/
https://www.ncbi.nlm.nih.gov/pubmed/28400561
http://dx.doi.org/10.1038/s41598-017-00854-w

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