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Imaging the dynamics of cardiac fiber orientation in vivo using 3D Ultrasound Backscatter Tensor Imaging

The assessment of myocardial fiber disarray is of major interest for the study of the progression of myocardial disease. However, time-resolved imaging of the myocardial structure remains unavailable in clinical practice. In this study, we introduce 3D Backscatter Tensor Imaging (3D-BTI), an entirel...

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Autores principales: Papadacci, Clement, Finel, Victor, Provost, Jean, Villemain, Olivier, Bruneval, Patrick, Gennisson, Jean-Luc, Tanter, Mickael, Fink, Mathias, Pernot, Mathieu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429761/
https://www.ncbi.nlm.nih.gov/pubmed/28400606
http://dx.doi.org/10.1038/s41598-017-00946-7
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author Papadacci, Clement
Finel, Victor
Provost, Jean
Villemain, Olivier
Bruneval, Patrick
Gennisson, Jean-Luc
Tanter, Mickael
Fink, Mathias
Pernot, Mathieu
author_facet Papadacci, Clement
Finel, Victor
Provost, Jean
Villemain, Olivier
Bruneval, Patrick
Gennisson, Jean-Luc
Tanter, Mickael
Fink, Mathias
Pernot, Mathieu
author_sort Papadacci, Clement
collection PubMed
description The assessment of myocardial fiber disarray is of major interest for the study of the progression of myocardial disease. However, time-resolved imaging of the myocardial structure remains unavailable in clinical practice. In this study, we introduce 3D Backscatter Tensor Imaging (3D-BTI), an entirely novel ultrasound-based imaging technique that can map the myocardial fibers orientation and its dynamics with a temporal resolution of 10 ms during a single cardiac cycle, non-invasively and in vivo in entire volumes. 3D-BTI is based on ultrafast volumetric ultrasound acquisitions, which are used to quantify the spatial coherence of backscattered echoes at each point of the volume. The capability of 3D-BTI to map the fibers orientation was evaluated in vitro in 5 myocardial samples. The helicoidal transmural variation of fiber angles was in good agreement with the one obtained by histological analysis. 3D-BTI was then performed to map the fiber orientation dynamics in vivo in the beating heart of an open-chest sheep at a volume rate of 90 volumes/s. Finally, the clinical feasibility of 3D-BTI was shown on a healthy volunteer. These initial results indicate that 3D-BTI could become a fully non-invasive technique to assess myocardial disarray at the bedside of patients.
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spelling pubmed-54297612017-05-15 Imaging the dynamics of cardiac fiber orientation in vivo using 3D Ultrasound Backscatter Tensor Imaging Papadacci, Clement Finel, Victor Provost, Jean Villemain, Olivier Bruneval, Patrick Gennisson, Jean-Luc Tanter, Mickael Fink, Mathias Pernot, Mathieu Sci Rep Article The assessment of myocardial fiber disarray is of major interest for the study of the progression of myocardial disease. However, time-resolved imaging of the myocardial structure remains unavailable in clinical practice. In this study, we introduce 3D Backscatter Tensor Imaging (3D-BTI), an entirely novel ultrasound-based imaging technique that can map the myocardial fibers orientation and its dynamics with a temporal resolution of 10 ms during a single cardiac cycle, non-invasively and in vivo in entire volumes. 3D-BTI is based on ultrafast volumetric ultrasound acquisitions, which are used to quantify the spatial coherence of backscattered echoes at each point of the volume. The capability of 3D-BTI to map the fibers orientation was evaluated in vitro in 5 myocardial samples. The helicoidal transmural variation of fiber angles was in good agreement with the one obtained by histological analysis. 3D-BTI was then performed to map the fiber orientation dynamics in vivo in the beating heart of an open-chest sheep at a volume rate of 90 volumes/s. Finally, the clinical feasibility of 3D-BTI was shown on a healthy volunteer. These initial results indicate that 3D-BTI could become a fully non-invasive technique to assess myocardial disarray at the bedside of patients. Nature Publishing Group UK 2017-04-11 /pmc/articles/PMC5429761/ /pubmed/28400606 http://dx.doi.org/10.1038/s41598-017-00946-7 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Papadacci, Clement
Finel, Victor
Provost, Jean
Villemain, Olivier
Bruneval, Patrick
Gennisson, Jean-Luc
Tanter, Mickael
Fink, Mathias
Pernot, Mathieu
Imaging the dynamics of cardiac fiber orientation in vivo using 3D Ultrasound Backscatter Tensor Imaging
title Imaging the dynamics of cardiac fiber orientation in vivo using 3D Ultrasound Backscatter Tensor Imaging
title_full Imaging the dynamics of cardiac fiber orientation in vivo using 3D Ultrasound Backscatter Tensor Imaging
title_fullStr Imaging the dynamics of cardiac fiber orientation in vivo using 3D Ultrasound Backscatter Tensor Imaging
title_full_unstemmed Imaging the dynamics of cardiac fiber orientation in vivo using 3D Ultrasound Backscatter Tensor Imaging
title_short Imaging the dynamics of cardiac fiber orientation in vivo using 3D Ultrasound Backscatter Tensor Imaging
title_sort imaging the dynamics of cardiac fiber orientation in vivo using 3d ultrasound backscatter tensor imaging
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429761/
https://www.ncbi.nlm.nih.gov/pubmed/28400606
http://dx.doi.org/10.1038/s41598-017-00946-7
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