Cargando…

Intestinal PPARδ protects against diet-induced obesity, insulin resistance and dyslipidemia

Peroxisome proliferator-activated receptor δ (PPARδ) is a ligand-activated transcription factor that has an important role in lipid metabolism. Activation of PPARδ stimulates fatty acid oxidation in adipose tissue and skeletal muscle and improves dyslipidemia in mice and humans. PPARδ is highly expr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Doktorova, Marcela, Zwarts, Irene, Zutphen, Tim van, Dijk, Theo H. van, Bloks, Vincent W., Harkema, Liesbeth, Bruin, Alain de, Downes, Michael, Evans, Ronald M., Verkade, Henkjan J., Jonker, Johan W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429805/ https://www.ncbi.nlm.nih.gov/pubmed/28404991 http://dx.doi.org/10.1038/s41598-017-00889-z

Ejemplares similares

Identification of the fructose transporter GLUT5 (SLC2A5) as a novel target of nuclear receptor LXR
por: Zwarts, Irene, et al.
Publicado: (2019)

Autocrine FGF1 signaling promotes glucose uptake in adipocytes
por: Nies, Vera J. M., et al.
Publicado: (2022)

Impaired Intestinal Farnesoid X Receptor Signaling in Cystic Fibrosis Mice
por: Ikpa, Pauline T., et al.
Publicado: (2019)

Bile Acid Sequestration via Colesevelam Reduces Bile Acid Hydrophobicity and Improves Liver Pathology in Cyp2c70(−/−) Mice with a Human-like Bile Acid Composition
por: Palmiotti, Anna, et al.
Publicado: (2023)

Smad3 Mediates Diabetic Dyslipidemia and Fatty Liver in db/db Mice by Targeting PPARδ
por: He, Huijun, et al.
Publicado: (2023)

Milk cholesterol concentration in mice is not affected by high cholesterol diet- or genetically-induced hypercholesterolaemia
por: Dimova, Lidiya G., et al.
Publicado: (2018)

Response to Spontaneous Cholemia in C57BL/6 Mice Predisposes to Liver Cancer in NASH
por: Ronda, Onne A.H.O., et al.
Publicado: (2022)

The Beneficial Effects of Apical Sodium‐Dependent Bile Acid Transporter Inactivation Depend on Dietary Fat Composition
por: van de Peppel, Ivo P., et al.
Publicado: (2020)

Hepatic Farnesoid X-Receptor Isoforms α2 and α4 Differentially Modulate Bile Salt and Lipoprotein Metabolism in Mice
por: Boesjes, Marije, et al.
Publicado: (2014)

Mice with a deficiency in Peroxisomal Membrane Protein 4 (PXMP4) display mild changes in hepatic lipid metabolism
por: Blankestijn, Maaike, et al.
Publicado: (2022)

NO-Donating NSAIDs, PPARδ, and Cancer: Does PPARδ Contribute to Colon Carcinogenesis?
por: Mackenzie, Gerardo G., et al.
Publicado: (2008)

PPAR-δ in Vascular Pathophysiology
por: Wang, Nanping
Publicado: (2008)

PPARγ and PPARδ as Modulators of Neoplasia and Cell Fate
por: Glazer, Robert I., et al.
Publicado: (2008)

Conditional Expression of Human PPARδ and a Dominant Negative Variant of hPPARδ In Vivo
por: Higgins, Larry G., et al.
Publicado: (2012)

Potential of therapeutic bile acids in the treatment of neonatal Hyperbilirubinemia
por: van der Schoor, Lori W. E., et al.
Publicado: (2021)

Investigating the Role of PPARβ/δ in Retinal Vascular Remodeling Using Pparβ/δ-Deficient Mice
por: Ho, Sze Yuan, et al.
Publicado: (2020)

Fibroblast Growth Factor Signaling in Metabolic Regulation
por: Nies, Vera J. M., et al.
Publicado: (2016)

PPAR α and PPAR γ Polymorphisms as risk factors for Dyslipidemia in a Chinese han population
por: Gu, Shu-Jun, et al.
Publicado: (2014)

MDG-1, a Potential Regulator of PPARα and PPARγ, Ameliorates Dyslipidemia in Mice
por: Wang, Xu, et al.
Publicado: (2017)

Structure-Based Virtual Screening and Discovery of New PPARδ/γ Dual Agonist and PPARδ and γ Agonists
por: Maltarollo, Vinicius G., et al.
Publicado: (2015)

Regulation of Muscle Fiber Type and Running Endurance by PPARδ
por: Wang, Yong-Xu, et al.
Publicado: (2004)

Insights into the Role of PPARβ/δ in NAFLD
por: Chen, Jiapeng, et al.
Publicado: (2018)

PPARβ/δ: Linking Metabolism to Regeneration
por: Magadum, Ajit, et al.
Publicado: (2018)

The Role of PPARβ/δ in Melanoma Metastasis
por: Lim, Jonathan Chee Woei, et al.
Publicado: (2018)

Glucose‐6‐Phosphate Regulates Hepatic Bile Acid Synthesis in Mice
por: Hoogerland, Joanne A., et al.
Publicado: (2019)

Inhibition of Doxorubicin-Induced Senescence by PPARδ Activation Agonists in Cardiac Muscle Cells: Cooperation between PPARδ and Bcl6
por: Altieri, Paola, et al.
Publicado: (2012)

Effects of the New Dual PPARα/δ Agonist GFT505 on Lipid and Glucose Homeostasis in Abdominally Obese Patients With Combined Dyslipidemia or Impaired Glucose Metabolism
por: Cariou, Bertrand, et al.
Publicado: (2011)

Ligand Modulated Antagonism of PPARγ by Genomic and Non-Genomic Actions of PPARδ
por: Gustafsson, Mattias C. U., et al.
Publicado: (2009)

Gamma‐glutamyl transferase and disease course in pediatric‐onset primary sclerosing cholangitis: A single‐center cohort study
por: Berhane, Besrat, et al.
Publicado: (2023)

Short‐term protein restriction at advanced age stimulates FGF21 signalling, energy expenditure and browning of white adipose tissue
por: Dommerholt, Marleen B., et al.
Publicado: (2020)

A Role for PPARβ/δ in Ocular Angiogenesis
por: Bishop-Bailey, David
Publicado: (2008)

Regulation of Cell Proliferation and Differentiation by PPARβ/δ
por: Müller, Rolf, et al.
Publicado: (2008)

Time (and PPARβ/δ) heals all wounds
por: Short, Ben
Publicado: (2009)

Spontaneous liver disease in wild-type C57BL/6JOlaHsd mice fed semisynthetic diet
por: Ronda, Onne A. H. O., et al.
Publicado: (2020)

Skin-Targeted Inhibition of PPAR β/δ by Selective Antagonists to Treat PPAR β/δ – Mediated Psoriasis-Like Skin Disease In Vivo
por: Hack, Katrin, et al.
Publicado: (2012)

A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis
por: Jonker, Johan W., et al.
Publicado: (2012)

PPARα Is Required for PPARδ Action in Regulation of Body Weight and Hepatic Steatosis in Mice
por: Garbacz, Wojciech G., et al.
Publicado: (2015)

Targeting Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) for Cancer Chemoprevention
por: Peters, Jeffrey M., et al.
Publicado: (2015)

Dual PPAR α/γ Agonism Normalizes Lipoprotein Profile of Renal Dyslipidemia
por: Samuelsson, O., et al.
Publicado: (2013)

PPAR-δ senses and orchestrates clearance of apoptotic cells to promote tolerance
por: Mukundan, Lata, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_5ermbjf7c1ciud7jo8arkv1fa6