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Interplay of buried histidine protonation and protein stability in prion misfolding

Misofolding of mammalian prion proteins (PrP) is believed to be the cause of a group of rare and fatal neurodegenerative diseases. Despite intense scrutiny however, the mechanism of the misfolding reaction remains unclear. We perform nuclear Magnetic Resonance and thermodynamic stability measurement...

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Detalles Bibliográficos
Autores principales:	Malevanets, Anatoly, Chong, P. Andrew, Hansen, D. Flemming, Rizk, Paul, Sun, Yulong, Lin, Hong, Muhandiram, Ranjith, Chakrabartty, Avi, Kay, Lewis E., Forman-Kay, Julie D., Wodak, Shoshana J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429843/ https://www.ncbi.nlm.nih.gov/pubmed/28408762 http://dx.doi.org/10.1038/s41598-017-00954-7

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