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Diagnosis of Splenic Lymphoma by Endoscopic Ultrasound Guided Fine Needle Aspiration: A Case Report and Review of the Literature

Introduction. Splenic tumor is usually found as an incidental finding on CT of abdomen. Traditionally, ultrasound (US) or computed tomography (CT) guided biopsies were employed for the purpose of sampling; however they have been reported to have a complication rate of 5.3%. Endoscopic ultrasound-fin...

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Autores principales: Darr, Umar, Khan, Zubair, Ali Khan, Muhammad, Renno, Anas, Alkully, Turki, Kamal, Sehrish, Hammad, Tariq, Alastal, Yaseen, Imran Khan, Muhammad, Nawras, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429928/
https://www.ncbi.nlm.nih.gov/pubmed/28540094
http://dx.doi.org/10.1155/2017/3602910
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author Darr, Umar
Khan, Zubair
Ali Khan, Muhammad
Renno, Anas
Alkully, Turki
Kamal, Sehrish
Hammad, Tariq
Alastal, Yaseen
Imran Khan, Muhammad
Nawras, Ali
author_facet Darr, Umar
Khan, Zubair
Ali Khan, Muhammad
Renno, Anas
Alkully, Turki
Kamal, Sehrish
Hammad, Tariq
Alastal, Yaseen
Imran Khan, Muhammad
Nawras, Ali
author_sort Darr, Umar
collection PubMed
description Introduction. Splenic tumor is usually found as an incidental finding on CT of abdomen. Traditionally, ultrasound (US) or computed tomography (CT) guided biopsies were employed for the purpose of sampling; however they have been reported to have a complication rate of 5.3%. Endoscopic ultrasound-fine needle aspiration (EUS-FNA) has been recently utilized for the purpose of sampling splenic tumors. In literature there are 7 reported instances where splenic lymphoma was diagnosed using EUS-FNA. We present a case of follicular B cell lymphoma of the spleen diagnosed using EUS-FNA. Case Report. 58-year-old female presented to her primary care physician for left upper quadrant abdominal pain for one week. Physical exam was significant for left upper quadrant tenderness. Her laboratory tests were within normal limits. She underwent CT scan of abdomen which revealed approximately 5 cm × 5 cm mass in spleen. EUS-FNA of the spleen revealed a large hypoechoic, heterogeneous, well-demarcated mass measuring 54.7 mm × 43.0 mm. Fine needle aspiration was performed, and the sample was submitted for cytology and flow cytometry. Flow cytometry revealed a lambda monotypic population of B cells displaying dim CD19 and CD10. Diagnosis of B cell non-Hodgkin low grade follicular lymphoma was made. Conclusion. Endoscopic ultrasound with fine needle aspiration is a very rare but safe, reliable method of diagnosis of splenic lymphomas.
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spelling pubmed-54299282017-05-24 Diagnosis of Splenic Lymphoma by Endoscopic Ultrasound Guided Fine Needle Aspiration: A Case Report and Review of the Literature Darr, Umar Khan, Zubair Ali Khan, Muhammad Renno, Anas Alkully, Turki Kamal, Sehrish Hammad, Tariq Alastal, Yaseen Imran Khan, Muhammad Nawras, Ali Case Rep Gastrointest Med Case Report Introduction. Splenic tumor is usually found as an incidental finding on CT of abdomen. Traditionally, ultrasound (US) or computed tomography (CT) guided biopsies were employed for the purpose of sampling; however they have been reported to have a complication rate of 5.3%. Endoscopic ultrasound-fine needle aspiration (EUS-FNA) has been recently utilized for the purpose of sampling splenic tumors. In literature there are 7 reported instances where splenic lymphoma was diagnosed using EUS-FNA. We present a case of follicular B cell lymphoma of the spleen diagnosed using EUS-FNA. Case Report. 58-year-old female presented to her primary care physician for left upper quadrant abdominal pain for one week. Physical exam was significant for left upper quadrant tenderness. Her laboratory tests were within normal limits. She underwent CT scan of abdomen which revealed approximately 5 cm × 5 cm mass in spleen. EUS-FNA of the spleen revealed a large hypoechoic, heterogeneous, well-demarcated mass measuring 54.7 mm × 43.0 mm. Fine needle aspiration was performed, and the sample was submitted for cytology and flow cytometry. Flow cytometry revealed a lambda monotypic population of B cells displaying dim CD19 and CD10. Diagnosis of B cell non-Hodgkin low grade follicular lymphoma was made. Conclusion. Endoscopic ultrasound with fine needle aspiration is a very rare but safe, reliable method of diagnosis of splenic lymphomas. Hindawi 2017 2017-04-30 /pmc/articles/PMC5429928/ /pubmed/28540094 http://dx.doi.org/10.1155/2017/3602910 Text en Copyright © 2017 Umar Darr et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Darr, Umar
Khan, Zubair
Ali Khan, Muhammad
Renno, Anas
Alkully, Turki
Kamal, Sehrish
Hammad, Tariq
Alastal, Yaseen
Imran Khan, Muhammad
Nawras, Ali
Diagnosis of Splenic Lymphoma by Endoscopic Ultrasound Guided Fine Needle Aspiration: A Case Report and Review of the Literature
title Diagnosis of Splenic Lymphoma by Endoscopic Ultrasound Guided Fine Needle Aspiration: A Case Report and Review of the Literature
title_full Diagnosis of Splenic Lymphoma by Endoscopic Ultrasound Guided Fine Needle Aspiration: A Case Report and Review of the Literature
title_fullStr Diagnosis of Splenic Lymphoma by Endoscopic Ultrasound Guided Fine Needle Aspiration: A Case Report and Review of the Literature
title_full_unstemmed Diagnosis of Splenic Lymphoma by Endoscopic Ultrasound Guided Fine Needle Aspiration: A Case Report and Review of the Literature
title_short Diagnosis of Splenic Lymphoma by Endoscopic Ultrasound Guided Fine Needle Aspiration: A Case Report and Review of the Literature
title_sort diagnosis of splenic lymphoma by endoscopic ultrasound guided fine needle aspiration: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429928/
https://www.ncbi.nlm.nih.gov/pubmed/28540094
http://dx.doi.org/10.1155/2017/3602910
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