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Viruses and miRNAs: More Friends than Foes

There is evidence that eukaryotic miRNAs (hereafter called host miRNAs) play a role in the replication and propagation of viruses. Expression or targeting of host miRNAs can be involved in cellular antiviral responses. Most times host miRNAs play a role in viral life-cycles and promote infection thr...

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Autores principales: Bruscella, Patrice, Bottini, Silvia, Baudesson, Camille, Pawlotsky, Jean-Michel, Feray, Cyrille, Trabucchi, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430039/
https://www.ncbi.nlm.nih.gov/pubmed/28555130
http://dx.doi.org/10.3389/fmicb.2017.00824
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author Bruscella, Patrice
Bottini, Silvia
Baudesson, Camille
Pawlotsky, Jean-Michel
Feray, Cyrille
Trabucchi, Michele
author_facet Bruscella, Patrice
Bottini, Silvia
Baudesson, Camille
Pawlotsky, Jean-Michel
Feray, Cyrille
Trabucchi, Michele
author_sort Bruscella, Patrice
collection PubMed
description There is evidence that eukaryotic miRNAs (hereafter called host miRNAs) play a role in the replication and propagation of viruses. Expression or targeting of host miRNAs can be involved in cellular antiviral responses. Most times host miRNAs play a role in viral life-cycles and promote infection through complex regulatory pathways. miRNAs can also be encoded by a viral genome and be expressed in the host cell. Viral miRNAs can share common sequences with host miRNAs or have totally different sequences. They can regulate a variety of biological processes involved in viral infection, including apoptosis, evasion of the immune response, or modulation of viral life-cycle phases. Overall, virus/miRNA pathway interaction is defined by a plethora of complex mechanisms, though not yet fully understood. This article review summarizes recent advances and novel biological concepts related to the understanding of miRNA expression, control and function during viral infections. The article also discusses potential therapeutic applications of this particular host–pathogen interaction.
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spelling pubmed-54300392017-05-29 Viruses and miRNAs: More Friends than Foes Bruscella, Patrice Bottini, Silvia Baudesson, Camille Pawlotsky, Jean-Michel Feray, Cyrille Trabucchi, Michele Front Microbiol Microbiology There is evidence that eukaryotic miRNAs (hereafter called host miRNAs) play a role in the replication and propagation of viruses. Expression or targeting of host miRNAs can be involved in cellular antiviral responses. Most times host miRNAs play a role in viral life-cycles and promote infection through complex regulatory pathways. miRNAs can also be encoded by a viral genome and be expressed in the host cell. Viral miRNAs can share common sequences with host miRNAs or have totally different sequences. They can regulate a variety of biological processes involved in viral infection, including apoptosis, evasion of the immune response, or modulation of viral life-cycle phases. Overall, virus/miRNA pathway interaction is defined by a plethora of complex mechanisms, though not yet fully understood. This article review summarizes recent advances and novel biological concepts related to the understanding of miRNA expression, control and function during viral infections. The article also discusses potential therapeutic applications of this particular host–pathogen interaction. Frontiers Media S.A. 2017-05-15 /pmc/articles/PMC5430039/ /pubmed/28555130 http://dx.doi.org/10.3389/fmicb.2017.00824 Text en Copyright © 2017 Bruscella, Bottini, Baudesson, Pawlotsky, Feray and Trabucchi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Bruscella, Patrice
Bottini, Silvia
Baudesson, Camille
Pawlotsky, Jean-Michel
Feray, Cyrille
Trabucchi, Michele
Viruses and miRNAs: More Friends than Foes
title Viruses and miRNAs: More Friends than Foes
title_full Viruses and miRNAs: More Friends than Foes
title_fullStr Viruses and miRNAs: More Friends than Foes
title_full_unstemmed Viruses and miRNAs: More Friends than Foes
title_short Viruses and miRNAs: More Friends than Foes
title_sort viruses and mirnas: more friends than foes
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430039/
https://www.ncbi.nlm.nih.gov/pubmed/28555130
http://dx.doi.org/10.3389/fmicb.2017.00824
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