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Molecular Determinants of Cephalopod Muscles and Their Implication in Muscle Regeneration
The ability to regenerate whole-body structures has been studied for many decades and is of particular interest for stem cell research due to its therapeutic potential. Several vertebrate and invertebrate species have been used as model systems to study pathways involved in regeneration in the past....
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430041/ https://www.ncbi.nlm.nih.gov/pubmed/28555185 http://dx.doi.org/10.3389/fcell.2017.00053 |
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author | Zullo, Letizia Fossati, Sara M. Imperadore, Pamela Nödl, Marie-Therese |
author_facet | Zullo, Letizia Fossati, Sara M. Imperadore, Pamela Nödl, Marie-Therese |
author_sort | Zullo, Letizia |
collection | PubMed |
description | The ability to regenerate whole-body structures has been studied for many decades and is of particular interest for stem cell research due to its therapeutic potential. Several vertebrate and invertebrate species have been used as model systems to study pathways involved in regeneration in the past. Among invertebrates, cephalopods are considered as highly evolved organisms, which exhibit elaborate behavioral characteristics when compared to other mollusks including active predation, extraordinary manipulation, and learning abilities. These are enabled by a complex nervous system and a number of adaptations of their body plan, which were acquired over evolutionary time. Some of these novel features show similarities to structures present in vertebrates and seem to have evolved through a convergent evolutionary process. Octopus vulgaris (the common octopus) is a representative of modern cephalopods and is characterized by a sophisticated motor and sensory system as well as highly developed cognitive capabilities. Due to its phylogenetic position and its high regenerative power the octopus has become of increasing interest for studies on regenerative processes. In this paper we provide an overview over the current knowledge of cephalopod muscle types and structures and present a possible link between these characteristics and their high regenerative potential. This may help identify conserved molecular pathways underlying regeneration in invertebrate and vertebrate animal species as well as discover new leads for targeted tissue treatments in humans. |
format | Online Article Text |
id | pubmed-5430041 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-54300412017-05-29 Molecular Determinants of Cephalopod Muscles and Their Implication in Muscle Regeneration Zullo, Letizia Fossati, Sara M. Imperadore, Pamela Nödl, Marie-Therese Front Cell Dev Biol Cell and Developmental Biology The ability to regenerate whole-body structures has been studied for many decades and is of particular interest for stem cell research due to its therapeutic potential. Several vertebrate and invertebrate species have been used as model systems to study pathways involved in regeneration in the past. Among invertebrates, cephalopods are considered as highly evolved organisms, which exhibit elaborate behavioral characteristics when compared to other mollusks including active predation, extraordinary manipulation, and learning abilities. These are enabled by a complex nervous system and a number of adaptations of their body plan, which were acquired over evolutionary time. Some of these novel features show similarities to structures present in vertebrates and seem to have evolved through a convergent evolutionary process. Octopus vulgaris (the common octopus) is a representative of modern cephalopods and is characterized by a sophisticated motor and sensory system as well as highly developed cognitive capabilities. Due to its phylogenetic position and its high regenerative power the octopus has become of increasing interest for studies on regenerative processes. In this paper we provide an overview over the current knowledge of cephalopod muscle types and structures and present a possible link between these characteristics and their high regenerative potential. This may help identify conserved molecular pathways underlying regeneration in invertebrate and vertebrate animal species as well as discover new leads for targeted tissue treatments in humans. Frontiers Media S.A. 2017-05-15 /pmc/articles/PMC5430041/ /pubmed/28555185 http://dx.doi.org/10.3389/fcell.2017.00053 Text en Copyright © 2017 Zullo, Fossati, Imperadore and Nödl. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Zullo, Letizia Fossati, Sara M. Imperadore, Pamela Nödl, Marie-Therese Molecular Determinants of Cephalopod Muscles and Their Implication in Muscle Regeneration |
title | Molecular Determinants of Cephalopod Muscles and Their Implication in Muscle Regeneration |
title_full | Molecular Determinants of Cephalopod Muscles and Their Implication in Muscle Regeneration |
title_fullStr | Molecular Determinants of Cephalopod Muscles and Their Implication in Muscle Regeneration |
title_full_unstemmed | Molecular Determinants of Cephalopod Muscles and Their Implication in Muscle Regeneration |
title_short | Molecular Determinants of Cephalopod Muscles and Their Implication in Muscle Regeneration |
title_sort | molecular determinants of cephalopod muscles and their implication in muscle regeneration |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430041/ https://www.ncbi.nlm.nih.gov/pubmed/28555185 http://dx.doi.org/10.3389/fcell.2017.00053 |
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