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The impact of presence of Hashimoto's thyroiditis on diagnostic accuracy of ultrasound‐guided fine‐needle aspiration biopsy in subcentimeter thyroid nodules: A retrospective study from FUSCC

The incidence of PTMC has been increasing in the recent years. This study aimed to investigate the diagnostic value of US‐FNA in thyroid nodules ≤1 cm and whether the presence of Hashimoto's thyroiditis (HT) in thyroid could influence the accuracy. The patients who accepted US‐FNA at FUSCC from...

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Autores principales: Gao, Lili, Ma, Ben, Zhou, Li, Wang, Yu, Yang, Shuwen, Qu, Ning, Gao, Yi, Ji, Qinghai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430084/
https://www.ncbi.nlm.nih.gov/pubmed/28382784
http://dx.doi.org/10.1002/cam4.997
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author Gao, Lili
Ma, Ben
Zhou, Li
Wang, Yu
Yang, Shuwen
Qu, Ning
Gao, Yi
Ji, Qinghai
author_facet Gao, Lili
Ma, Ben
Zhou, Li
Wang, Yu
Yang, Shuwen
Qu, Ning
Gao, Yi
Ji, Qinghai
author_sort Gao, Lili
collection PubMed
description The incidence of PTMC has been increasing in the recent years. This study aimed to investigate the diagnostic value of US‐FNA in thyroid nodules ≤1 cm and whether the presence of Hashimoto's thyroiditis (HT) in thyroid could influence the accuracy. The patients who accepted US‐FNA at FUSCC from December 2012 to November 2015 and followed our criteria were enrolled in this study. We extracted the cytological, pathological, and follow‐up US/US‐FNA data of patients with subcentimeter nodules. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), false‐negative rate (FNR), false‐positive rate (FPR), and AUC were calculated to define FNA diagnostic performance in patients. The association of HT with cytological results was analyzed in univariate and multivariate logistic regression analysis. In total, 754 patients with 817 subcentimeter nodules were collected to comprise the FUSCC cohort. Of the 817 nodules, the cytological results were ND/UNS in 80 nodules (9.8%), benign in 74 (9.1%), AUS/FLUS in 80 (9.8%), FN/SFN in 6 (0.7%), suspicious for malignancy (SM) in 222 (27.2%), and malignant in 355 (43.5%). The sensitivity, specificity, PPV, NPV, and AUC of US‐FNA for the subcentimeter nodules were 98.8%, 90.5%, 98.8%, 90.5%, and 94.7%, respectively. In comparison with HT‐positive subcentimeter nodules, the diagnostic value of US‐FNA for HT‐negative nodules was significantly higher (HT‐positive: AUC = 91.6%, HT‐negative: AUC = 95.9%, P = 0.028). The coexistent HT was found to increase the risk of the FNR and indeterminate cytological results. US‐FNA demonstrated an effective method for diagnosis of subcentimeter thyroid nodules with a low nondiagnostic rate in our study. The presence of HT in thyroid could be a risk factor for the increased FNR and indeterminate cytological results during US‐FNA.
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spelling pubmed-54300842017-05-17 The impact of presence of Hashimoto's thyroiditis on diagnostic accuracy of ultrasound‐guided fine‐needle aspiration biopsy in subcentimeter thyroid nodules: A retrospective study from FUSCC Gao, Lili Ma, Ben Zhou, Li Wang, Yu Yang, Shuwen Qu, Ning Gao, Yi Ji, Qinghai Cancer Med Clinical Cancer Research The incidence of PTMC has been increasing in the recent years. This study aimed to investigate the diagnostic value of US‐FNA in thyroid nodules ≤1 cm and whether the presence of Hashimoto's thyroiditis (HT) in thyroid could influence the accuracy. The patients who accepted US‐FNA at FUSCC from December 2012 to November 2015 and followed our criteria were enrolled in this study. We extracted the cytological, pathological, and follow‐up US/US‐FNA data of patients with subcentimeter nodules. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), false‐negative rate (FNR), false‐positive rate (FPR), and AUC were calculated to define FNA diagnostic performance in patients. The association of HT with cytological results was analyzed in univariate and multivariate logistic regression analysis. In total, 754 patients with 817 subcentimeter nodules were collected to comprise the FUSCC cohort. Of the 817 nodules, the cytological results were ND/UNS in 80 nodules (9.8%), benign in 74 (9.1%), AUS/FLUS in 80 (9.8%), FN/SFN in 6 (0.7%), suspicious for malignancy (SM) in 222 (27.2%), and malignant in 355 (43.5%). The sensitivity, specificity, PPV, NPV, and AUC of US‐FNA for the subcentimeter nodules were 98.8%, 90.5%, 98.8%, 90.5%, and 94.7%, respectively. In comparison with HT‐positive subcentimeter nodules, the diagnostic value of US‐FNA for HT‐negative nodules was significantly higher (HT‐positive: AUC = 91.6%, HT‐negative: AUC = 95.9%, P = 0.028). The coexistent HT was found to increase the risk of the FNR and indeterminate cytological results. US‐FNA demonstrated an effective method for diagnosis of subcentimeter thyroid nodules with a low nondiagnostic rate in our study. The presence of HT in thyroid could be a risk factor for the increased FNR and indeterminate cytological results during US‐FNA. John Wiley and Sons Inc. 2017-04-05 /pmc/articles/PMC5430084/ /pubmed/28382784 http://dx.doi.org/10.1002/cam4.997 Text en © 2017 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Cancer Research
Gao, Lili
Ma, Ben
Zhou, Li
Wang, Yu
Yang, Shuwen
Qu, Ning
Gao, Yi
Ji, Qinghai
The impact of presence of Hashimoto's thyroiditis on diagnostic accuracy of ultrasound‐guided fine‐needle aspiration biopsy in subcentimeter thyroid nodules: A retrospective study from FUSCC
title The impact of presence of Hashimoto's thyroiditis on diagnostic accuracy of ultrasound‐guided fine‐needle aspiration biopsy in subcentimeter thyroid nodules: A retrospective study from FUSCC
title_full The impact of presence of Hashimoto's thyroiditis on diagnostic accuracy of ultrasound‐guided fine‐needle aspiration biopsy in subcentimeter thyroid nodules: A retrospective study from FUSCC
title_fullStr The impact of presence of Hashimoto's thyroiditis on diagnostic accuracy of ultrasound‐guided fine‐needle aspiration biopsy in subcentimeter thyroid nodules: A retrospective study from FUSCC
title_full_unstemmed The impact of presence of Hashimoto's thyroiditis on diagnostic accuracy of ultrasound‐guided fine‐needle aspiration biopsy in subcentimeter thyroid nodules: A retrospective study from FUSCC
title_short The impact of presence of Hashimoto's thyroiditis on diagnostic accuracy of ultrasound‐guided fine‐needle aspiration biopsy in subcentimeter thyroid nodules: A retrospective study from FUSCC
title_sort impact of presence of hashimoto's thyroiditis on diagnostic accuracy of ultrasound‐guided fine‐needle aspiration biopsy in subcentimeter thyroid nodules: a retrospective study from fuscc
topic Clinical Cancer Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430084/
https://www.ncbi.nlm.nih.gov/pubmed/28382784
http://dx.doi.org/10.1002/cam4.997
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