The Effects of smoking status and smoking history on patients with brain metastases from lung cancer
There is limited data on the effects of smoking on lung cancer patients with brain metastases. This single institution retrospective study of patients with brain metastases from lung cancer who received stereotactic radiosurgery assessed whether smoking history is associated with overall survival, l...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430088/ https://www.ncbi.nlm.nih.gov/pubmed/28401684 http://dx.doi.org/10.1002/cam4.1058 |
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author | Shenker, Rachel F. McTyre, Emory R. Ruiz, Jimmy Weaver, Kathryn E. Cramer, Christina Alphonse‐Sullivan, Natalie K. Farris, Michael Petty, William J. Bonomi, Marcelo R. Watabe, Kounosuke Laxton, Adrian W. Tatter, Stephen B. Warren, Graham W. Chan, Michael D. |
author_facet | Shenker, Rachel F. McTyre, Emory R. Ruiz, Jimmy Weaver, Kathryn E. Cramer, Christina Alphonse‐Sullivan, Natalie K. Farris, Michael Petty, William J. Bonomi, Marcelo R. Watabe, Kounosuke Laxton, Adrian W. Tatter, Stephen B. Warren, Graham W. Chan, Michael D. |
author_sort | Shenker, Rachel F. |
collection | PubMed |
description | There is limited data on the effects of smoking on lung cancer patients with brain metastases. This single institution retrospective study of patients with brain metastases from lung cancer who received stereotactic radiosurgery assessed whether smoking history is associated with overall survival, local control, rate of new brain metastases (brain metastasis velocity), and likelihood of neurologic death after brain metastases. Patients were stratified by adenocarcinoma versus nonadenocarcinoma histologies. Kaplan–Meier analysis was performed for survival endpoints. Competing risk analysis was performed for neurologic death analysis to account for risk of nonneurologic death. Separate linear regression and multivariate analyses were performed to estimate the brain metastasis velocity. Of 366 patients included in the analysis, the median age was 63, 54% were male and, 60% were diagnosed with adenocarcinoma. Current smoking was reported by 37% and 91% had a smoking history. Current smoking status and pack‐year history of smoking had no effect on overall survival. There was a trend for an increased risk of neurologic death in nonadenocarcinoma patients who continued to smoke (14%, 35%, and 46% at 6/12/24 months) compared with patients who did not smoke (12%, 23%, and 30%, P = 0.053). Cumulative pack years smoking was associated with an increase in neurologic death for nonadenocarcinoma patients (HR = 1.01, CI: 1.00–1.02, P = 0.046). Increased pack‐year history increased brain metastasis velocity in multivariate analysis for overall patients (P = 0.026). Current smokers with nonadenocarcinoma lung cancers had a trend toward greater neurologic death than nonsmokers. Cumulative pack years smoking is associated with a greater brain metastasis velocity. |
format | Online Article Text |
id | pubmed-5430088 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-54300882017-05-17 The Effects of smoking status and smoking history on patients with brain metastases from lung cancer Shenker, Rachel F. McTyre, Emory R. Ruiz, Jimmy Weaver, Kathryn E. Cramer, Christina Alphonse‐Sullivan, Natalie K. Farris, Michael Petty, William J. Bonomi, Marcelo R. Watabe, Kounosuke Laxton, Adrian W. Tatter, Stephen B. Warren, Graham W. Chan, Michael D. Cancer Med Clinical Cancer Research There is limited data on the effects of smoking on lung cancer patients with brain metastases. This single institution retrospective study of patients with brain metastases from lung cancer who received stereotactic radiosurgery assessed whether smoking history is associated with overall survival, local control, rate of new brain metastases (brain metastasis velocity), and likelihood of neurologic death after brain metastases. Patients were stratified by adenocarcinoma versus nonadenocarcinoma histologies. Kaplan–Meier analysis was performed for survival endpoints. Competing risk analysis was performed for neurologic death analysis to account for risk of nonneurologic death. Separate linear regression and multivariate analyses were performed to estimate the brain metastasis velocity. Of 366 patients included in the analysis, the median age was 63, 54% were male and, 60% were diagnosed with adenocarcinoma. Current smoking was reported by 37% and 91% had a smoking history. Current smoking status and pack‐year history of smoking had no effect on overall survival. There was a trend for an increased risk of neurologic death in nonadenocarcinoma patients who continued to smoke (14%, 35%, and 46% at 6/12/24 months) compared with patients who did not smoke (12%, 23%, and 30%, P = 0.053). Cumulative pack years smoking was associated with an increase in neurologic death for nonadenocarcinoma patients (HR = 1.01, CI: 1.00–1.02, P = 0.046). Increased pack‐year history increased brain metastasis velocity in multivariate analysis for overall patients (P = 0.026). Current smokers with nonadenocarcinoma lung cancers had a trend toward greater neurologic death than nonsmokers. Cumulative pack years smoking is associated with a greater brain metastasis velocity. John Wiley and Sons Inc. 2017-04-12 /pmc/articles/PMC5430088/ /pubmed/28401684 http://dx.doi.org/10.1002/cam4.1058 Text en © 2017 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Cancer Research Shenker, Rachel F. McTyre, Emory R. Ruiz, Jimmy Weaver, Kathryn E. Cramer, Christina Alphonse‐Sullivan, Natalie K. Farris, Michael Petty, William J. Bonomi, Marcelo R. Watabe, Kounosuke Laxton, Adrian W. Tatter, Stephen B. Warren, Graham W. Chan, Michael D. The Effects of smoking status and smoking history on patients with brain metastases from lung cancer |
title | The Effects of smoking status and smoking history on patients with brain metastases from lung cancer |
title_full | The Effects of smoking status and smoking history on patients with brain metastases from lung cancer |
title_fullStr | The Effects of smoking status and smoking history on patients with brain metastases from lung cancer |
title_full_unstemmed | The Effects of smoking status and smoking history on patients with brain metastases from lung cancer |
title_short | The Effects of smoking status and smoking history on patients with brain metastases from lung cancer |
title_sort | effects of smoking status and smoking history on patients with brain metastases from lung cancer |
topic | Clinical Cancer Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430088/ https://www.ncbi.nlm.nih.gov/pubmed/28401684 http://dx.doi.org/10.1002/cam4.1058 |
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