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Noninvasive characterization of pancreatic tumor mouse models using magnetic resonance imaging

The preclinical models of pancreatic adenocarcinoma provide an alternative means for determining the mechanisms of malignancy and possibilities for treatments, thus representing a resource of immense potential for cancer treatment in medicine. To evaluate different tumor models, quantifiable magneti...

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Detalles Bibliográficos
Autores principales: Farr, Navid, Wang, Yak‐Nam, D'Andrea, Samantha, Gravelle, Kayla M, Hwang, Joo Ha, Lee, Donghoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430104/
https://www.ncbi.nlm.nih.gov/pubmed/28390098
http://dx.doi.org/10.1002/cam4.1062
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author Farr, Navid
Wang, Yak‐Nam
D'Andrea, Samantha
Gravelle, Kayla M
Hwang, Joo Ha
Lee, Donghoon
author_facet Farr, Navid
Wang, Yak‐Nam
D'Andrea, Samantha
Gravelle, Kayla M
Hwang, Joo Ha
Lee, Donghoon
author_sort Farr, Navid
collection PubMed
description The preclinical models of pancreatic adenocarcinoma provide an alternative means for determining the mechanisms of malignancy and possibilities for treatments, thus representing a resource of immense potential for cancer treatment in medicine. To evaluate different tumor models, quantifiable magnetic resonance imaging (MRI) techniques can play a significant role in identifying valuable in vivo biomarkers of tumor characteristics. We characterized three models of pancreatic cancer with multiparametric MRI techniques. Tumor stromal density of each tumor was measured using diffusion‐weighted imaging and magnetization transfer (MT‐MRI). Histologic measurement showed a similar trend with tumor fibrosis levels. Results indicated that MRI measurements can serve as a valuable tool in identifying and evaluating tumor characteristics.
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spelling pubmed-54301042017-05-17 Noninvasive characterization of pancreatic tumor mouse models using magnetic resonance imaging Farr, Navid Wang, Yak‐Nam D'Andrea, Samantha Gravelle, Kayla M Hwang, Joo Ha Lee, Donghoon Cancer Med Cancer Biology The preclinical models of pancreatic adenocarcinoma provide an alternative means for determining the mechanisms of malignancy and possibilities for treatments, thus representing a resource of immense potential for cancer treatment in medicine. To evaluate different tumor models, quantifiable magnetic resonance imaging (MRI) techniques can play a significant role in identifying valuable in vivo biomarkers of tumor characteristics. We characterized three models of pancreatic cancer with multiparametric MRI techniques. Tumor stromal density of each tumor was measured using diffusion‐weighted imaging and magnetization transfer (MT‐MRI). Histologic measurement showed a similar trend with tumor fibrosis levels. Results indicated that MRI measurements can serve as a valuable tool in identifying and evaluating tumor characteristics. John Wiley and Sons Inc. 2017-04-07 /pmc/articles/PMC5430104/ /pubmed/28390098 http://dx.doi.org/10.1002/cam4.1062 Text en © 2017 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cancer Biology
Farr, Navid
Wang, Yak‐Nam
D'Andrea, Samantha
Gravelle, Kayla M
Hwang, Joo Ha
Lee, Donghoon
Noninvasive characterization of pancreatic tumor mouse models using magnetic resonance imaging
title Noninvasive characterization of pancreatic tumor mouse models using magnetic resonance imaging
title_full Noninvasive characterization of pancreatic tumor mouse models using magnetic resonance imaging
title_fullStr Noninvasive characterization of pancreatic tumor mouse models using magnetic resonance imaging
title_full_unstemmed Noninvasive characterization of pancreatic tumor mouse models using magnetic resonance imaging
title_short Noninvasive characterization of pancreatic tumor mouse models using magnetic resonance imaging
title_sort noninvasive characterization of pancreatic tumor mouse models using magnetic resonance imaging
topic Cancer Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430104/
https://www.ncbi.nlm.nih.gov/pubmed/28390098
http://dx.doi.org/10.1002/cam4.1062
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