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Noninvasive characterization of pancreatic tumor mouse models using magnetic resonance imaging
The preclinical models of pancreatic adenocarcinoma provide an alternative means for determining the mechanisms of malignancy and possibilities for treatments, thus representing a resource of immense potential for cancer treatment in medicine. To evaluate different tumor models, quantifiable magneti...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430104/ https://www.ncbi.nlm.nih.gov/pubmed/28390098 http://dx.doi.org/10.1002/cam4.1062 |
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author | Farr, Navid Wang, Yak‐Nam D'Andrea, Samantha Gravelle, Kayla M Hwang, Joo Ha Lee, Donghoon |
author_facet | Farr, Navid Wang, Yak‐Nam D'Andrea, Samantha Gravelle, Kayla M Hwang, Joo Ha Lee, Donghoon |
author_sort | Farr, Navid |
collection | PubMed |
description | The preclinical models of pancreatic adenocarcinoma provide an alternative means for determining the mechanisms of malignancy and possibilities for treatments, thus representing a resource of immense potential for cancer treatment in medicine. To evaluate different tumor models, quantifiable magnetic resonance imaging (MRI) techniques can play a significant role in identifying valuable in vivo biomarkers of tumor characteristics. We characterized three models of pancreatic cancer with multiparametric MRI techniques. Tumor stromal density of each tumor was measured using diffusion‐weighted imaging and magnetization transfer (MT‐MRI). Histologic measurement showed a similar trend with tumor fibrosis levels. Results indicated that MRI measurements can serve as a valuable tool in identifying and evaluating tumor characteristics. |
format | Online Article Text |
id | pubmed-5430104 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-54301042017-05-17 Noninvasive characterization of pancreatic tumor mouse models using magnetic resonance imaging Farr, Navid Wang, Yak‐Nam D'Andrea, Samantha Gravelle, Kayla M Hwang, Joo Ha Lee, Donghoon Cancer Med Cancer Biology The preclinical models of pancreatic adenocarcinoma provide an alternative means for determining the mechanisms of malignancy and possibilities for treatments, thus representing a resource of immense potential for cancer treatment in medicine. To evaluate different tumor models, quantifiable magnetic resonance imaging (MRI) techniques can play a significant role in identifying valuable in vivo biomarkers of tumor characteristics. We characterized three models of pancreatic cancer with multiparametric MRI techniques. Tumor stromal density of each tumor was measured using diffusion‐weighted imaging and magnetization transfer (MT‐MRI). Histologic measurement showed a similar trend with tumor fibrosis levels. Results indicated that MRI measurements can serve as a valuable tool in identifying and evaluating tumor characteristics. John Wiley and Sons Inc. 2017-04-07 /pmc/articles/PMC5430104/ /pubmed/28390098 http://dx.doi.org/10.1002/cam4.1062 Text en © 2017 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Cancer Biology Farr, Navid Wang, Yak‐Nam D'Andrea, Samantha Gravelle, Kayla M Hwang, Joo Ha Lee, Donghoon Noninvasive characterization of pancreatic tumor mouse models using magnetic resonance imaging |
title | Noninvasive characterization of pancreatic tumor mouse models using magnetic resonance imaging |
title_full | Noninvasive characterization of pancreatic tumor mouse models using magnetic resonance imaging |
title_fullStr | Noninvasive characterization of pancreatic tumor mouse models using magnetic resonance imaging |
title_full_unstemmed | Noninvasive characterization of pancreatic tumor mouse models using magnetic resonance imaging |
title_short | Noninvasive characterization of pancreatic tumor mouse models using magnetic resonance imaging |
title_sort | noninvasive characterization of pancreatic tumor mouse models using magnetic resonance imaging |
topic | Cancer Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430104/ https://www.ncbi.nlm.nih.gov/pubmed/28390098 http://dx.doi.org/10.1002/cam4.1062 |
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