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Rapid‐eye‐movement sleep‐predominant central sleep apnea relieved by positive airway pressure: a case report

Central Sleep Apnea (CSA) is characterized by intermittent apneas and hypopneas during sleep that result from absent central respiratory drive. CSA occurs almost exclusively during non‐rapid‐eye‐movement (NREM) sleep due to enhanced neuronal ventilatory drive during REM sleep that makes central apne...

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Autores principales: Jouett, Noah P., Smith, Michael L., Watenpaugh, Donald E., Siddiqui, Maryam, Ahmad, Maleeha, Siddiqui, Farrukh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430122/
https://www.ncbi.nlm.nih.gov/pubmed/28483860
http://dx.doi.org/10.14814/phy2.13254
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author Jouett, Noah P.
Smith, Michael L.
Watenpaugh, Donald E.
Siddiqui, Maryam
Ahmad, Maleeha
Siddiqui, Farrukh
author_facet Jouett, Noah P.
Smith, Michael L.
Watenpaugh, Donald E.
Siddiqui, Maryam
Ahmad, Maleeha
Siddiqui, Farrukh
author_sort Jouett, Noah P.
collection PubMed
description Central Sleep Apnea (CSA) is characterized by intermittent apneas and hypopneas during sleep that result from absent central respiratory drive. CSA occurs almost exclusively during non‐rapid‐eye‐movement (NREM) sleep due to enhanced neuronal ventilatory drive during REM sleep that makes central apneas highly unlikely to form. A 45‐year‐old obese African American female presented with co‐existing Obstructive Sleep Apnea (OSA) and CSA, not in the form of mixed or complex sleep apnea. Peculiarly, her CSA occurred only during rapid‐eye‐movement (REM) sleep, which is exceedingly rare. The patient's CSA was resolved when appropriate positive airway pressure (PAP) was prescribed. Our patient remains stable and has reported significant benefit from PAP usage. We offer possible neuro‐physiological mechanisms herein, including enhanced loop gain and/or malfunction or malformation of the pre‐Botzinger nucleus or other neurological process, that could explain the unique findings of this case.
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spelling pubmed-54301222017-05-17 Rapid‐eye‐movement sleep‐predominant central sleep apnea relieved by positive airway pressure: a case report Jouett, Noah P. Smith, Michael L. Watenpaugh, Donald E. Siddiqui, Maryam Ahmad, Maleeha Siddiqui, Farrukh Physiol Rep Case Reports Central Sleep Apnea (CSA) is characterized by intermittent apneas and hypopneas during sleep that result from absent central respiratory drive. CSA occurs almost exclusively during non‐rapid‐eye‐movement (NREM) sleep due to enhanced neuronal ventilatory drive during REM sleep that makes central apneas highly unlikely to form. A 45‐year‐old obese African American female presented with co‐existing Obstructive Sleep Apnea (OSA) and CSA, not in the form of mixed or complex sleep apnea. Peculiarly, her CSA occurred only during rapid‐eye‐movement (REM) sleep, which is exceedingly rare. The patient's CSA was resolved when appropriate positive airway pressure (PAP) was prescribed. Our patient remains stable and has reported significant benefit from PAP usage. We offer possible neuro‐physiological mechanisms herein, including enhanced loop gain and/or malfunction or malformation of the pre‐Botzinger nucleus or other neurological process, that could explain the unique findings of this case. John Wiley and Sons Inc. 2017-05-08 /pmc/articles/PMC5430122/ /pubmed/28483860 http://dx.doi.org/10.14814/phy2.13254 Text en © 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Jouett, Noah P.
Smith, Michael L.
Watenpaugh, Donald E.
Siddiqui, Maryam
Ahmad, Maleeha
Siddiqui, Farrukh
Rapid‐eye‐movement sleep‐predominant central sleep apnea relieved by positive airway pressure: a case report
title Rapid‐eye‐movement sleep‐predominant central sleep apnea relieved by positive airway pressure: a case report
title_full Rapid‐eye‐movement sleep‐predominant central sleep apnea relieved by positive airway pressure: a case report
title_fullStr Rapid‐eye‐movement sleep‐predominant central sleep apnea relieved by positive airway pressure: a case report
title_full_unstemmed Rapid‐eye‐movement sleep‐predominant central sleep apnea relieved by positive airway pressure: a case report
title_short Rapid‐eye‐movement sleep‐predominant central sleep apnea relieved by positive airway pressure: a case report
title_sort rapid‐eye‐movement sleep‐predominant central sleep apnea relieved by positive airway pressure: a case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430122/
https://www.ncbi.nlm.nih.gov/pubmed/28483860
http://dx.doi.org/10.14814/phy2.13254
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