Epithelioid angiosarcoma arising in a uterine leiomyoma with associated elevated CA-125: A case report

We describe the case of a 67 year old female with longstanding uterine leiomyomas who presented with fatigue, weight loss, elevated CA-125 and an enlarging mass arising from the posterior uterine fundus. Histologic sections of the mass contained a leiomyoma with interspersed foci of malignant epithe...

Descripción completa

Detalles Bibliográficos
Autores principales: Strickland, Sarah V., Kilgore, Mark R., Simons, Elise J., Rendi, Mara H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430145/
https://www.ncbi.nlm.nih.gov/pubmed/28540360
http://dx.doi.org/10.1016/j.gore.2017.05.001
_version_ 1783236170527801344
author Strickland, Sarah V.
Kilgore, Mark R.
Simons, Elise J.
Rendi, Mara H.
author_facet Strickland, Sarah V.
Kilgore, Mark R.
Simons, Elise J.
Rendi, Mara H.
author_sort Strickland, Sarah V.
collection PubMed
description We describe the case of a 67 year old female with longstanding uterine leiomyomas who presented with fatigue, weight loss, elevated CA-125 and an enlarging mass arising from the posterior uterine fundus. Histologic sections of the mass contained a leiomyoma with interspersed foci of malignant epithelioid cells forming anastomosing vascular channels. The neoplastic cells were diffusely positive for CD31 and FLI1, supporting the morphologic impression of epithelioid angiosarcoma. Few cases of epithelioid angiosarcoma arising within a leiomyoma have been described. In this report we discuss this association and describe its relation with elevated CA-125.
format Online
Article
Text
id pubmed-5430145
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-54301452017-05-24 Epithelioid angiosarcoma arising in a uterine leiomyoma with associated elevated CA-125: A case report Strickland, Sarah V. Kilgore, Mark R. Simons, Elise J. Rendi, Mara H. Gynecol Oncol Rep Case Report We describe the case of a 67 year old female with longstanding uterine leiomyomas who presented with fatigue, weight loss, elevated CA-125 and an enlarging mass arising from the posterior uterine fundus. Histologic sections of the mass contained a leiomyoma with interspersed foci of malignant epithelioid cells forming anastomosing vascular channels. The neoplastic cells were diffusely positive for CD31 and FLI1, supporting the morphologic impression of epithelioid angiosarcoma. Few cases of epithelioid angiosarcoma arising within a leiomyoma have been described. In this report we discuss this association and describe its relation with elevated CA-125. Elsevier 2017-05-05 /pmc/articles/PMC5430145/ /pubmed/28540360 http://dx.doi.org/10.1016/j.gore.2017.05.001 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Strickland, Sarah V.
Kilgore, Mark R.
Simons, Elise J.
Rendi, Mara H.
Epithelioid angiosarcoma arising in a uterine leiomyoma with associated elevated CA-125: A case report
title Epithelioid angiosarcoma arising in a uterine leiomyoma with associated elevated CA-125: A case report
title_full Epithelioid angiosarcoma arising in a uterine leiomyoma with associated elevated CA-125: A case report
title_fullStr Epithelioid angiosarcoma arising in a uterine leiomyoma with associated elevated CA-125: A case report
title_full_unstemmed Epithelioid angiosarcoma arising in a uterine leiomyoma with associated elevated CA-125: A case report
title_short Epithelioid angiosarcoma arising in a uterine leiomyoma with associated elevated CA-125: A case report
title_sort epithelioid angiosarcoma arising in a uterine leiomyoma with associated elevated ca-125: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430145/
https://www.ncbi.nlm.nih.gov/pubmed/28540360
http://dx.doi.org/10.1016/j.gore.2017.05.001
work_keys_str_mv AT stricklandsarahv epithelioidangiosarcomaarisinginauterineleiomyomawithassociatedelevatedca125acasereport
AT kilgoremarkr epithelioidangiosarcomaarisinginauterineleiomyomawithassociatedelevatedca125acasereport
AT simonselisej epithelioidangiosarcomaarisinginauterineleiomyomawithassociatedelevatedca125acasereport
AT rendimarah epithelioidangiosarcomaarisinginauterineleiomyomawithassociatedelevatedca125acasereport

Ejemplares similares