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Laminar Localization and Projection-Specific Properties of Presubicular Neurons Targeting the Lateral Mammillary Nucleus, Thalamus, or Medial Entorhinal Cortex

The presubiculum (PrS) is part of an interconnected network of distributed brain regions where individual neurons signal the animals heading direction. PrS sends axons to medial entorhinal cortex (MEC), it is reciprocally connected with anterior thalamic nuclei (ATNs), and it sends feedback projecti...

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Autores principales: Huang, Li-Wen, Simonnet, Jean, Nassar, Mérie, Richevaux, Louis, Lofredi, Roxanne, Fricker, Desdemona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430300/
https://www.ncbi.nlm.nih.gov/pubmed/28508034
http://dx.doi.org/10.1523/ENEURO.0370-16.2017
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author Huang, Li-Wen
Simonnet, Jean
Nassar, Mérie
Richevaux, Louis
Lofredi, Roxanne
Fricker, Desdemona
author_facet Huang, Li-Wen
Simonnet, Jean
Nassar, Mérie
Richevaux, Louis
Lofredi, Roxanne
Fricker, Desdemona
author_sort Huang, Li-Wen
collection PubMed
description The presubiculum (PrS) is part of an interconnected network of distributed brain regions where individual neurons signal the animals heading direction. PrS sends axons to medial entorhinal cortex (MEC), it is reciprocally connected with anterior thalamic nuclei (ATNs), and it sends feedback projections to the lateral mammillary nucleus (LMN), involved in generating the head direction signal. The intrinsic properties of projecting neurons will influence the pathway-specific transmission of activity. Here, we used projection-specific labeling of presubicular neurons to identify MEC-, LMN-, and ATN-projecting neurons in mice. MEC-projecting neurons located in superficial layers II/III were mostly regular spiking pyramidal neurons, and we also identified a Martinotti-type GABAergic neuron. The cell bodies of LMN-projecting neurons were located in a well-delimited area in the middle portion of the PrS, which corresponds to layer IV. The physiology of LMN projecting, pyramidal neurons stood out with a tendency to fire in bursts of action potentials (APs) with rapid onset. These properties may be uniquely adapted to reliably transmit visual landmark information with short latency to upstream LMN. Neurons projecting to ATN were located in layers V/VI, and they were mostly regular spiking pyramidal neurons. Unsupervised cluster analysis of intrinsic properties suggested distinct physiological features for the different categories of projection neurons, with some similarities between MEC- and ATN-projecting neurons. Projection-specific subpopulations may serve separate functions in the PrS and may be engaged differently in transmitting head direction related information.
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spelling pubmed-54303002017-05-15 Laminar Localization and Projection-Specific Properties of Presubicular Neurons Targeting the Lateral Mammillary Nucleus, Thalamus, or Medial Entorhinal Cortex Huang, Li-Wen Simonnet, Jean Nassar, Mérie Richevaux, Louis Lofredi, Roxanne Fricker, Desdemona eNeuro New Research The presubiculum (PrS) is part of an interconnected network of distributed brain regions where individual neurons signal the animals heading direction. PrS sends axons to medial entorhinal cortex (MEC), it is reciprocally connected with anterior thalamic nuclei (ATNs), and it sends feedback projections to the lateral mammillary nucleus (LMN), involved in generating the head direction signal. The intrinsic properties of projecting neurons will influence the pathway-specific transmission of activity. Here, we used projection-specific labeling of presubicular neurons to identify MEC-, LMN-, and ATN-projecting neurons in mice. MEC-projecting neurons located in superficial layers II/III were mostly regular spiking pyramidal neurons, and we also identified a Martinotti-type GABAergic neuron. The cell bodies of LMN-projecting neurons were located in a well-delimited area in the middle portion of the PrS, which corresponds to layer IV. The physiology of LMN projecting, pyramidal neurons stood out with a tendency to fire in bursts of action potentials (APs) with rapid onset. These properties may be uniquely adapted to reliably transmit visual landmark information with short latency to upstream LMN. Neurons projecting to ATN were located in layers V/VI, and they were mostly regular spiking pyramidal neurons. Unsupervised cluster analysis of intrinsic properties suggested distinct physiological features for the different categories of projection neurons, with some similarities between MEC- and ATN-projecting neurons. Projection-specific subpopulations may serve separate functions in the PrS and may be engaged differently in transmitting head direction related information. Society for Neuroscience 2017-05-15 /pmc/articles/PMC5430300/ /pubmed/28508034 http://dx.doi.org/10.1523/ENEURO.0370-16.2017 Text en Copyright © 2017 Huang et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle New Research
Huang, Li-Wen
Simonnet, Jean
Nassar, Mérie
Richevaux, Louis
Lofredi, Roxanne
Fricker, Desdemona
Laminar Localization and Projection-Specific Properties of Presubicular Neurons Targeting the Lateral Mammillary Nucleus, Thalamus, or Medial Entorhinal Cortex
title Laminar Localization and Projection-Specific Properties of Presubicular Neurons Targeting the Lateral Mammillary Nucleus, Thalamus, or Medial Entorhinal Cortex
title_full Laminar Localization and Projection-Specific Properties of Presubicular Neurons Targeting the Lateral Mammillary Nucleus, Thalamus, or Medial Entorhinal Cortex
title_fullStr Laminar Localization and Projection-Specific Properties of Presubicular Neurons Targeting the Lateral Mammillary Nucleus, Thalamus, or Medial Entorhinal Cortex
title_full_unstemmed Laminar Localization and Projection-Specific Properties of Presubicular Neurons Targeting the Lateral Mammillary Nucleus, Thalamus, or Medial Entorhinal Cortex
title_short Laminar Localization and Projection-Specific Properties of Presubicular Neurons Targeting the Lateral Mammillary Nucleus, Thalamus, or Medial Entorhinal Cortex
title_sort laminar localization and projection-specific properties of presubicular neurons targeting the lateral mammillary nucleus, thalamus, or medial entorhinal cortex
topic New Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430300/
https://www.ncbi.nlm.nih.gov/pubmed/28508034
http://dx.doi.org/10.1523/ENEURO.0370-16.2017
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