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Inhibition of late sodium current suppresses calcium-related ventricular arrhythmias by reducing the phosphorylation of CaMK-II and sodium channel expressions

Cardiac arrhythmias associated with intracellular calcium inhomeostasis are refractory to antiarrhythmic therapy. We hypothesized that late sodium current (I (Na)) contributed to the calcium-related arrhythmias. Monophasic action potential duration at 90% completion of repolarization (MAPD(90)) was...

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Detalles Bibliográficos
Autores principales:	Wei, Xiao-Hong, Yu, Shan-Dong, Ren, Lu, Huang, Si-Hui, Yang, Qiao-Mei, Wang, Ping, Chu, Yan-Peng, Yang, Wei, Ding, Yan-Sheng, Huo, Yong, Wu, Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430524/ https://www.ncbi.nlm.nih.gov/pubmed/28428622 http://dx.doi.org/10.1038/s41598-017-01056-0

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