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Potential therapeutic action of nitrite in sickle cell disease

Sickle cell disease is caused by a mutant form of hemoglobin that polymerizes under hypoxic conditions, increasing rigidity, fragility, calcium influx-mediated dehydration, and adhesivity of red blood cells. Increased red cell fragility results in hemolysis, which reduces nitric oxide (NO) bioavaila...

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Detalles Bibliográficos
Autores principales:	Wajih, Nadeem, Basu, Swati, Jailwala, Anuj, Kim, Hee Won, Ostrowski, David, Perlegas, Andreas, Bolden, Crystal A., Buechler, Nancy L., Gladwin, Mark T., Caudell, David L., Rahbar, Elaheh, Alexander-Miller, Martha A., Vachharajani, Vidula, Kim-Shapiro, Daniel B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430577/ https://www.ncbi.nlm.nih.gov/pubmed/28511346 http://dx.doi.org/10.1016/j.redox.2017.05.006

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