Optogenetic interrogation reveals separable G-protein-dependent and -independent signalling linking G-protein-coupled receptors to the circadian oscillator

BACKGROUND: Endogenous circadian oscillators distributed across the mammalian body are synchronised among themselves and with external time via a variety of signalling molecules, some of which interact with G-protein-coupled receptors (GPCRs). GPCRs can regulate cell physiology via pathways originat...

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Detalles Bibliográficos
Autores principales: Bailes, Helena J., Milosavljevic, Nina, Zhuang, Ling-Yu, Gerrard, Elliot J., Nishiguchi, Tomoki, Ozawa, Takeaki, Lucas, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430609/
https://www.ncbi.nlm.nih.gov/pubmed/28506231
http://dx.doi.org/10.1186/s12915-017-0380-8

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