Mechanisms underlying cognitive deficits in a mouse model for Costello Syndrome are distinct from other RASopathy mouse models

RASopathies, characterized by germline mutations in genes encoding proteins of the RAS-ERK signaling pathway, show overlapping phenotypes, which manifest themselves with a varying severity of intellectual disability. However, it is unclear to what extent they share the same downstream pathophysiolog...

Descripción completa

Detalles Bibliográficos
Autores principales: Schreiber, Jadwiga, Grimbergen, Laura-Anne, Overwater, Iris, Vaart, Thijs van der, Stedehouder, Jeffrey, Schuhmacher, Alberto J., Guerra, Carmen, Kushner, Steven A., Jaarsma, Dick, Elgersma, Ype
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430680/
https://www.ncbi.nlm.nih.gov/pubmed/28455524
http://dx.doi.org/10.1038/s41598-017-01218-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430680/
https://www.ncbi.nlm.nih.gov/pubmed/28455524
http://dx.doi.org/10.1038/s41598-017-01218-0

Ejemplares similares