Cargando…
Mechanisms underlying cognitive deficits in a mouse model for Costello Syndrome are distinct from other RASopathy mouse models
RASopathies, characterized by germline mutations in genes encoding proteins of the RAS-ERK signaling pathway, show overlapping phenotypes, which manifest themselves with a varying severity of intellectual disability. However, it is unclear to what extent they share the same downstream pathophysiolog...
Autores principales: | Schreiber, Jadwiga, Grimbergen, Laura-Anne, Overwater, Iris, Vaart, Thijs van der, Stedehouder, Jeffrey, Schuhmacher, Alberto J., Guerra, Carmen, Kushner, Steven A., Jaarsma, Dick, Elgersma, Ype |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430680/ https://www.ncbi.nlm.nih.gov/pubmed/28455524 http://dx.doi.org/10.1038/s41598-017-01218-0 |
Ejemplares similares
-
MEK inhibition ameliorates social behavior phenotypes in a Spred1 knockout mouse model for RASopathy disorders
por: Borrie, Sarah C., et al.
Publicado: (2021) -
In vivo synaptic transmission and morphology in mouse models of Tuberous sclerosis, Fragile X syndrome, Neurofibromatosis type 1, and Costello syndrome
por: Wang, Tiantian, et al.
Publicado: (2015) -
A brain proteomic investigation of rapamycin effects in the Tsc1(+/−) mouse model
por: Wesseling, Hendrik, et al.
Publicado: (2017) -
Effects of antiepileptic drugs in a new TSC/mTOR‐dependent epilepsy mouse model
por: Koene, Linda M. C., et al.
Publicado: (2019) -
Ellizabeth Costello /
por: Coetzee, J. M., 1940-
Publicado: (2004)