Lamins and nesprin-1 mediate inside-out mechanical coupling in muscle cell precursors through FHOD1

LINC complexes are crucial for the response of muscle cell precursors to the rigidity of their environment, but the mechanisms explaining this behaviour are not known. Here we show that pathogenic mutations in LMNA or SYNE-1 responsible for severe muscle dystrophies reduced the ability of human musc...

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Detalles Bibliográficos
Autores principales: Schwartz, Christine, Fischer, Martina, Mamchaoui, Kamel, Bigot, Anne, Lok, Thevy, Verdier, Claude, Duperray, Alain, Michel, Richard, Holt, Ian, Voit, Thomas, Quijano-Roy, Suzanna, Bonne, Gisèle, Coirault, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430732/
https://www.ncbi.nlm.nih.gov/pubmed/28455503
http://dx.doi.org/10.1038/s41598-017-01324-z

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