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One-Step Fabrication of pH-Responsive Membranes and Microcapsules through Interfacial H-Bond Polymer Complexation

Biocompatible microencapsulation is of widespread interest for the targeted delivery of active species in fields such as pharmaceuticals, cosmetics and agro-chemistry. Capsules obtained by the self-assembly of polymers at interfaces enable the combination of responsiveness to stimuli, biocompatibili...

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Autores principales: Dupré de Baubigny, Julien, Trégouët, Corentin, Salez, Thomas, Pantoustier, Nadège, Perrin, Patrick, Reyssat, Mathilde, Monteux, Cécile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430763/
https://www.ncbi.nlm.nih.gov/pubmed/28455535
http://dx.doi.org/10.1038/s41598-017-01374-3
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author Dupré de Baubigny, Julien
Trégouët, Corentin
Salez, Thomas
Pantoustier, Nadège
Perrin, Patrick
Reyssat, Mathilde
Monteux, Cécile
author_facet Dupré de Baubigny, Julien
Trégouët, Corentin
Salez, Thomas
Pantoustier, Nadège
Perrin, Patrick
Reyssat, Mathilde
Monteux, Cécile
author_sort Dupré de Baubigny, Julien
collection PubMed
description Biocompatible microencapsulation is of widespread interest for the targeted delivery of active species in fields such as pharmaceuticals, cosmetics and agro-chemistry. Capsules obtained by the self-assembly of polymers at interfaces enable the combination of responsiveness to stimuli, biocompatibility and scaled up production. Here, we present a one-step method to produce in situ membranes at oil-water interfaces, based on the hydrogen bond complexation of polymers between H-bond acceptor and donor in the oil and aqueous phases, respectively. This robust process is realized through different methods, to obtain capsules of various sizes, from the micrometer scale using microfluidics or rotor-stator emulsification up to the centimeter scale using drop dripping. The polymer layer exhibits unique self-healing and pH-responsive properties. The membrane is viscoelastic at pH = 3, softens as pH is progressively raised, and eventually dissolves above pH = 6 to release the oil phase. This one-step method of preparation paves the way to the production of large quantities of functional capsules.
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spelling pubmed-54307632017-05-16 One-Step Fabrication of pH-Responsive Membranes and Microcapsules through Interfacial H-Bond Polymer Complexation Dupré de Baubigny, Julien Trégouët, Corentin Salez, Thomas Pantoustier, Nadège Perrin, Patrick Reyssat, Mathilde Monteux, Cécile Sci Rep Article Biocompatible microencapsulation is of widespread interest for the targeted delivery of active species in fields such as pharmaceuticals, cosmetics and agro-chemistry. Capsules obtained by the self-assembly of polymers at interfaces enable the combination of responsiveness to stimuli, biocompatibility and scaled up production. Here, we present a one-step method to produce in situ membranes at oil-water interfaces, based on the hydrogen bond complexation of polymers between H-bond acceptor and donor in the oil and aqueous phases, respectively. This robust process is realized through different methods, to obtain capsules of various sizes, from the micrometer scale using microfluidics or rotor-stator emulsification up to the centimeter scale using drop dripping. The polymer layer exhibits unique self-healing and pH-responsive properties. The membrane is viscoelastic at pH = 3, softens as pH is progressively raised, and eventually dissolves above pH = 6 to release the oil phase. This one-step method of preparation paves the way to the production of large quantities of functional capsules. Nature Publishing Group UK 2017-04-28 /pmc/articles/PMC5430763/ /pubmed/28455535 http://dx.doi.org/10.1038/s41598-017-01374-3 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Dupré de Baubigny, Julien
Trégouët, Corentin
Salez, Thomas
Pantoustier, Nadège
Perrin, Patrick
Reyssat, Mathilde
Monteux, Cécile
One-Step Fabrication of pH-Responsive Membranes and Microcapsules through Interfacial H-Bond Polymer Complexation
title One-Step Fabrication of pH-Responsive Membranes and Microcapsules through Interfacial H-Bond Polymer Complexation
title_full One-Step Fabrication of pH-Responsive Membranes and Microcapsules through Interfacial H-Bond Polymer Complexation
title_fullStr One-Step Fabrication of pH-Responsive Membranes and Microcapsules through Interfacial H-Bond Polymer Complexation
title_full_unstemmed One-Step Fabrication of pH-Responsive Membranes and Microcapsules through Interfacial H-Bond Polymer Complexation
title_short One-Step Fabrication of pH-Responsive Membranes and Microcapsules through Interfacial H-Bond Polymer Complexation
title_sort one-step fabrication of ph-responsive membranes and microcapsules through interfacial h-bond polymer complexation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430763/
https://www.ncbi.nlm.nih.gov/pubmed/28455535
http://dx.doi.org/10.1038/s41598-017-01374-3
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