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CRL4B(DCAF11) E3 ligase targets p21 for degradation to control cell cycle progression in human osteosarcoma cells

Cell cycle progression in mammals is strictly controlled by a number of cyclin-dependent kinases (CDKs) and CDK inhibitors (CKIs), the expression of which is often dysregulated in cancer cells. Our previous work revealed that Cullin 4B (CUL4B), a critical component of the Cullin4B-RING E3 ligase com...

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Detalles Bibliográficos
Autores principales:	Chen, Zhi, Wang, Kun, Hou, Canglong, Jiang, Kaibiao, Chen, Bin, Chen, Jianwei, Lao, Lifeng, Qian, Lie, Zhong, Guibin, Liu, Zude, Zhang, Caiguo, Shen, Hongxing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430835/ https://www.ncbi.nlm.nih.gov/pubmed/28446751 http://dx.doi.org/10.1038/s41598-017-01344-9

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