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Cation and voltage dependence of lidocaine inhibition of the hyperpolarization-activated cyclic nucleotide-gated HCN1 channel

Lidocaine is known to inhibit the hyperpolarization-activated mixed cation current (I(h)) in cardiac myocytes and neurons, as well in cells transfected with cloned Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) channels. However, the molecular mechanism of I(h) inhibition by this drug has...

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Detalles Bibliográficos
Autores principales:	Putrenko, Igor, Yip, Raymond, Schwarz, Stephan K. W., Accili, Eric A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430837/ https://www.ncbi.nlm.nih.gov/pubmed/28455536 http://dx.doi.org/10.1038/s41598-017-01253-x

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