Cargando…

Cation and voltage dependence of lidocaine inhibition of the hyperpolarization-activated cyclic nucleotide-gated HCN1 channel

Lidocaine is known to inhibit the hyperpolarization-activated mixed cation current (I(h)) in cardiac myocytes and neurons, as well in cells transfected with cloned Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) channels. However, the molecular mechanism of I(h) inhibition by this drug has...

Descripción completa

Detalles Bibliográficos
Autores principales:	Putrenko, Igor, Yip, Raymond, Schwarz, Stephan K. W., Accili, Eric A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430837/ https://www.ncbi.nlm.nih.gov/pubmed/28455536 http://dx.doi.org/10.1038/s41598-017-01253-x

Ejemplares similares

The HCN domain couples voltage gating and cAMP response in hyperpolarization-activated cyclic nucleotide-gated channels
por: Porro, Alessandro, et al.
Publicado: (2019)

The impact of hyperpolarization-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium KCNQ/Kv7 channels on primary microglia function
por: Vay, Sabine Ulrike, et al.
Publicado: (2020)

Direct Regulation of Hyperpolarization-Activated Cyclic-Nucleotide Gated (HCN1) Channels by Cannabinoids
por: Mayar, Sultan, et al.
Publicado: (2022)

Novel Potassium Channels in Kidney Mitochondria: The Hyperpolarization-Activated and Cyclic Nucleotide-Gated HCN Channels
por: León-Aparicio, Daniel, et al.
Publicado: (2019)

Bibliometric analysis of hyperpolarization-activated cyclic nucleotide-gated (HCN)channels research (2004-2020)
por: Tian, Chuanxi, et al.
Publicado: (2022)

Association between Reversal in the Expression of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channel and Age-Related Atrial Fibrillation
por: Li, Yao-Dong, et al.
Publicado: (2014)

A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels
por: Saponaro, Andrea, et al.
Publicado: (2018)

Gating mechanism of hyperpolarization-activated HCN pacemaker channels
por: Ramentol, Rosamary, et al.
Publicado: (2020)

Hyperpolarization-Activated Cyclic Nucleotide-Gated Non-selective (HCN) Ion Channels Regulate Human and Murine Urinary Bladder Contractility
por: Mader, Felix, et al.
Publicado: (2018)

Hyperpolarization-Activated Cyclic Nucleotide-Gated Ion (HCN) Channels Regulate PC12 Cell Differentiation Toward Sympathetic Neuron
por: Zhong, Li-Ying, et al.
Publicado: (2019)

Coordinating heart morphogenesis: A novel role for hyperpolarization-activated cyclic nucleotide-gated (HCN) channels during cardiogenesis in Xenopus laevis
por: Pitcairn, Emily, et al.
Publicado: (2017)

Locally injected ivabradine inhibits carrageenan-induced pain and inflammatory responses via hyperpolarization-activated cyclic nucleotide-gated (HCN) channels
por: Miyake, Saki, et al.
Publicado: (2019)

Crizotinib inhibits hyperpolarization-activated cyclic nucleotide-gated channel 4 activity
por: Zhang, Zhushan, et al.
Publicado: (2017)

Mechanical transduction of cytoplasmic-to-transmembrane-domain movements in a hyperpolarization-activated cyclic nucleotide–gated cation channel
por: Gross, Christine, et al.
Publicado: (2018)

Voltage-Controlled Gating at the Intracellular Entrance to a Hyperpolarization-Activated Cation Channel
por: Rothberg, Brad S., et al.
Publicado: (2002)

The expression of hyperpolarization activated cyclic nucleotide gated (HCN) channels in the rat ovary are dependent on the type of cell and the reproductive age of the animal: a laboratory investigation
por: Yeh, John, et al.
Publicado: (2008)

Alterations in hyperpolarization-activated cyclic nucleotidegated cation channel (HCN) expression in the hippocampus following pilocarpine-induced status epilepticus
por: Oh, Yun-Jung, et al.
Publicado: (2012)

Dysfunctional Hyperpolarization-Activated Cyclic Nucleotide-gated Ion Channels in Cardiac Diseases
por: Zhao, Xiaoqi, et al.
Publicado: (2016)

Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels: An Emerging Role in Neurodegenerative Diseases
por: Chang, Xiaoli, et al.
Publicado: (2019)

Computational Prediction of Phosphoinositide Binding to Hyperpolarization-Activated Cyclic-Nucleotide Gated Channels
por: Claveras Cabezudo, Ainara, et al.
Publicado: (2022)

Integrated Allosteric Model of Voltage Gating of Hcn Channels
por: Altomare, Claudia, et al.
Publicado: (2001)

Helix breaking transition in the S4 of HCN channel is critical for hyperpolarization-dependent gating
por: Kasimova, Marina A, et al.
Publicado: (2019)

Structural Identification of the Pacemaker Cells and Expression of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels in the Heart of the Wild Atlantic Cod, Gadus morhua (Linnaeus, 1758)
por: Capillo, Gioele, et al.
Publicado: (2021)

Properties of Hyperpolarization-Activated Pacemaker Current Defined by Coassembly of Hcn1 and Hcn2 Subunits and Basal Modulation by Cyclic Nucleotide
por: Chen, Shan, et al.
Publicado: (2001)

The HCN Channel Voltage Sensor Undergoes A Large Downward Motion During Hyperpolarization
por: Dai, Gucan, et al.
Publicado: (2019)

Regulation of Gating and Rundown of HCN Hyperpolarization-activated Channels by Exogenous and Endogenous PIP(2)
por: Pian, Phillip, et al.
Publicado: (2006)

Bipolar switching by HCN voltage sensor underlies hyperpolarization activation
por: Cowgill, John, et al.
Publicado: (2019)

Hyperpolarization‐activated cyclic nucleotide‐gated channels working as pacemaker channels in colonic interstitial cells of Cajal
por: Choi, Seok, et al.
Publicado: (2021)

A Novel Carbamoyloxy Arylalkanoyl Arylpiperazine Compound (SKL-NP) Inhibits Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channel Currents in Rat Dorsal Root Ganglion Neurons
por: Chung, Gehoon, et al.
Publicado: (2012)

Critical role for hyperpolarization-activated cyclic nucleotide-gated channel 2 in the AIF-mediated apoptosis
por: Norberg, Erik, et al.
Publicado: (2010)

Repurposing hyperpolarization‐activated cyclic nucleotide‐gated channels as a novel therapy for breast cancer
por: Mok, Ka‐Chun, et al.
Publicado: (2021)

SUMOylation of the Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 Increases Surface Expression and the Maximal Conductance of the Hyperpolarization-Activated Current
por: Parker, Anna R., et al.
Publicado: (2017)

Evolutionary and Structural Perspectives of Plant Cyclic Nucleotide-Gated Cation Channels
por: Zelman, Alice K., et al.
Publicado: (2012)

Retraction: A Novel Carbamoyloxy Arylalkanoyl Arylpiperazine Compound (SKL-NP) Inhibits Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channel Currents in Rat Dorsal Root Ganglion Neurons
por: Chung, Gehoon, et al.
Publicado: (2012)

Investigating cyclic nucleotide and cyclic dinucleotide binding to HCN channels by surface plasmon resonance
por: Hayoz, Sebastien, et al.
Publicado: (2017)

Hyperpolarization-activated and cyclic nucleotide-gated channels are differentially expressed in juxtaglomerular cells in the olfactory bulb of mice
por: Fried, Hans-Ulrich, et al.
Publicado: (2010)

Differential expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits during hippocampal development in the mouse
por: Seo, Hyunhyo, et al.
Publicado: (2015)

Alterations in SUMOylation of the hyperpolarization‐activated cyclic nucleotide‐gated ion channel 2 during persistent inflammation
por: Forster, Lori A., et al.
Publicado: (2020)

The structure and function of TRIP8b, an auxiliary subunit of hyperpolarization-activated cyclic-nucleotide gated channels
por: Han, Ye, et al.
Publicado: (2020)

Architecture of the HCN selectivity filter and control of cation permeation
por: Macri, Vincenzo, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_s874qaagi7h1kllinlbb9ug58b