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Host-probiotic interaction: new insight into the role of the endocannabinoid system by in vivo and ex vivo approaches
The endocannabinoid system plays an important role in regulating inflammation in several chronic or anomalous gut inflammatory diseases. In vivo and ex vivo studies showed that 30 days treatment with a probiotic mix activated the endocannabinoid system in zebrafish. These results highlight the poten...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430882/ https://www.ncbi.nlm.nih.gov/pubmed/28455493 http://dx.doi.org/10.1038/s41598-017-01322-1 |
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author | Gioacchini, Giorgia Rossi, Giacomo Carnevali, Oliana |
author_facet | Gioacchini, Giorgia Rossi, Giacomo Carnevali, Oliana |
author_sort | Gioacchini, Giorgia |
collection | PubMed |
description | The endocannabinoid system plays an important role in regulating inflammation in several chronic or anomalous gut inflammatory diseases. In vivo and ex vivo studies showed that 30 days treatment with a probiotic mix activated the endocannabinoid system in zebrafish. These results highlight the potential of this probiotic mixture to regulate immune cell function, by inducing gene expression of toll-like receptors and other immune related molecules. Furthermore, TUNEL assay showed a decrease in the number of apoptotic cells, and this finding was supported by a reduction in pro-apoptotic factors and an increase in anti-apoptotic molecules. The results presented here strengthen the molecular mechanisms activated by probiotic mix controlling immune response and inflammation. |
format | Online Article Text |
id | pubmed-5430882 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-54308822017-05-16 Host-probiotic interaction: new insight into the role of the endocannabinoid system by in vivo and ex vivo approaches Gioacchini, Giorgia Rossi, Giacomo Carnevali, Oliana Sci Rep Article The endocannabinoid system plays an important role in regulating inflammation in several chronic or anomalous gut inflammatory diseases. In vivo and ex vivo studies showed that 30 days treatment with a probiotic mix activated the endocannabinoid system in zebrafish. These results highlight the potential of this probiotic mixture to regulate immune cell function, by inducing gene expression of toll-like receptors and other immune related molecules. Furthermore, TUNEL assay showed a decrease in the number of apoptotic cells, and this finding was supported by a reduction in pro-apoptotic factors and an increase in anti-apoptotic molecules. The results presented here strengthen the molecular mechanisms activated by probiotic mix controlling immune response and inflammation. Nature Publishing Group UK 2017-04-28 /pmc/articles/PMC5430882/ /pubmed/28455493 http://dx.doi.org/10.1038/s41598-017-01322-1 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Gioacchini, Giorgia Rossi, Giacomo Carnevali, Oliana Host-probiotic interaction: new insight into the role of the endocannabinoid system by in vivo and ex vivo approaches |
title | Host-probiotic interaction: new insight into the role of the endocannabinoid system by in vivo and ex vivo approaches |
title_full | Host-probiotic interaction: new insight into the role of the endocannabinoid system by in vivo and ex vivo approaches |
title_fullStr | Host-probiotic interaction: new insight into the role of the endocannabinoid system by in vivo and ex vivo approaches |
title_full_unstemmed | Host-probiotic interaction: new insight into the role of the endocannabinoid system by in vivo and ex vivo approaches |
title_short | Host-probiotic interaction: new insight into the role of the endocannabinoid system by in vivo and ex vivo approaches |
title_sort | host-probiotic interaction: new insight into the role of the endocannabinoid system by in vivo and ex vivo approaches |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430882/ https://www.ncbi.nlm.nih.gov/pubmed/28455493 http://dx.doi.org/10.1038/s41598-017-01322-1 |
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