Indole alkaloid sulfonic acids from an aqueous extract of Isatis indigotica roots and their antiviral activity

Six new indole alkaloid sulfonic acids (1–6), together with two analogues (7 and 8) that were previously reported as synthetic products, were isolated from an aqueous extract of the Isatis indigotica root. Their structures including the absolute configurations were determined by spectroscopic data a...

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Detalles Bibliográficos
Autores principales: Meng, Lingjie, Guo, Qinglan, Liu, Yufeng, Chen, Minghua, Li, Yuhuan, Jiang, Jiandong, Shi, Jiangong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430897/
https://www.ncbi.nlm.nih.gov/pubmed/28540170
http://dx.doi.org/10.1016/j.apsb.2017.04.003
Descripción
Sumario:Six new indole alkaloid sulfonic acids (1–6), together with two analogues (7 and 8) that were previously reported as synthetic products, were isolated from an aqueous extract of the Isatis indigotica root. Their structures including the absolute configurations were determined by spectroscopic data analysis, combined with enzyme hydrolysis and comparison of experimental circular dichroism and calculated electronic circular dichroism spectra. In the preliminary assay, compounds 2 and 4 showed antiviral activity against Coxsackie virus B3 and influenza virus A/Hanfang/359/95 (H3N2), respectively.

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