Oxidation of protein-bound methionine in Photofrin-photodynamic therapy-treated human tumor cells explored by methionine-containing peptide enrichment and quantitative proteomics approach

In Photofrin-mediated photodynamic therapy (PDT), cell fate can be modulated by the subcellular location of Photofrin. PDT triggers oxidative damage to target cells, including the methionine (Met) oxidation of proteins. Here, we developed a new Met-containing peptide enrichment protocol combined wit...

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Detalles Bibliográficos
Autores principales: Hsieh, Ya-Ju, Chien, Kun-Yi, Yang, I-Fang, Lee, I-Neng, Wu, Chia-Chun, Huang, Tung-Yung, Yu, Jau-Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431048/
https://www.ncbi.nlm.nih.gov/pubmed/28465586
http://dx.doi.org/10.1038/s41598-017-01409-9

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