Lipopolysaccharide-induced NF-κB nuclear translocation is primarily dependent on MyD88, but TNFα expression requires TRIF and MyD88

TLR4 signalling through the MyD88 and TRIF-dependent pathways initiates translocation of the transcription factor NF-κB into the nucleus. In cell population studies using mathematical modeling and functional analyses, Cheng et al. suggested that LPS-driven activation of MyD88, in the absence of TRIF...

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Detalles Bibliográficos
Autores principales: Sakai, Jiro, Cammarota, Eugenia, Wright, John A., Cicuta, Pietro, Gottschalk, Rachel A., Li, Ning, Fraser, Iain D. C., Bryant, Clare E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431130/
https://www.ncbi.nlm.nih.gov/pubmed/28469251
http://dx.doi.org/10.1038/s41598-017-01600-y

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