Investigation of cationicity and structure of pseudin-2 analogues for enhanced bacterial selectivity and anti-inflammatory activity

Pseudin-2 (Ps), isolated from the frog Pseudis paradoxa, exhibits potent antibacterial activity and cytotoxicity. To develop antimicrobial peptides with anti-inflammatory activity and low cytotoxicity, we designed Ps analogues with Lys substitutions, resulting in elevated amphipathic α-helical struc...

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Detalles Bibliográficos
Autores principales: Jeon, Dasom, Jeong, Min-Cheol, Jacob, Binu, Bang, Jeong Kyu, Kim, Eun-Hee, Cheong, Chaejoon, Jung, In Duk, Park, Yoonkyung, Kim, Yangmee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431190/
https://www.ncbi.nlm.nih.gov/pubmed/28469145
http://dx.doi.org/10.1038/s41598-017-01474-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431190/
https://www.ncbi.nlm.nih.gov/pubmed/28469145
http://dx.doi.org/10.1038/s41598-017-01474-0

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