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Histopathological and immunohistochemical study in keratocystic odontogenic tumors: Predictive factors of recurrence

The aim of the present study was to identify the most useful markers for predicting recurrence of keratocystic odontogenic tumors (KCOTs). A total of 65 tumor samples from 63 patients diagnosed with typical parakeratinized cysts and KCOTs between 1992 and 2014 were retrospectively studied. Clinical...

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Autores principales: Naruse, Tomofumi, Yamashita, Kentaro, Yanamoto, Souichi, Rokutanda, Satoshi, Matsushita, Yuki, Sakamoto, Yuki, Sakamoto, Hiroshi, Ikeda, Hisazumi, Ikeda, Tohru, Asahina, Izumi, Umeda, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431266/
https://www.ncbi.nlm.nih.gov/pubmed/28521454
http://dx.doi.org/10.3892/ol.2017.5905
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author Naruse, Tomofumi
Yamashita, Kentaro
Yanamoto, Souichi
Rokutanda, Satoshi
Matsushita, Yuki
Sakamoto, Yuki
Sakamoto, Hiroshi
Ikeda, Hisazumi
Ikeda, Tohru
Asahina, Izumi
Umeda, Masahiro
author_facet Naruse, Tomofumi
Yamashita, Kentaro
Yanamoto, Souichi
Rokutanda, Satoshi
Matsushita, Yuki
Sakamoto, Yuki
Sakamoto, Hiroshi
Ikeda, Hisazumi
Ikeda, Tohru
Asahina, Izumi
Umeda, Masahiro
author_sort Naruse, Tomofumi
collection PubMed
description The aim of the present study was to identify the most useful markers for predicting recurrence of keratocystic odontogenic tumors (KCOTs). A total of 65 tumor samples from 63 patients diagnosed with typical parakeratinized cysts and KCOTs between 1992 and 2014 were retrospectively studied. Clinical and histopathological data and treatment modality were reviewed. In addition, the expression profiles of Ki-67, cluster of differentiation (CD)34 and podoplanin were assessed using immunohistochemistry. The association between these factors and the rate of KCOT recurrence was evaluated. The presence of daughter cysts, epithelial islands and high Ki-67, CD34 and podoplanin expression levels were revealed to be associated with tumor recurrence. In particular, univariate analysis revealed that high CD34 expression levels were significantly associated with tumor recurrence (P=0.034), as was conservative surgical treatment (P=0.003). Multivariate analysis revealed that conservative treatment was the greatest independent risk factor for tumor recurrence (odds ratio=13.337; P=0.018). These results suggest that overexpression of CD34 may be a potent predictor of tumor recurrence and radical treatment of the teeth that are in contact with the tumors is recommended in order to prevent tumor recurrence.
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spelling pubmed-54312662017-05-17 Histopathological and immunohistochemical study in keratocystic odontogenic tumors: Predictive factors of recurrence Naruse, Tomofumi Yamashita, Kentaro Yanamoto, Souichi Rokutanda, Satoshi Matsushita, Yuki Sakamoto, Yuki Sakamoto, Hiroshi Ikeda, Hisazumi Ikeda, Tohru Asahina, Izumi Umeda, Masahiro Oncol Lett Articles The aim of the present study was to identify the most useful markers for predicting recurrence of keratocystic odontogenic tumors (KCOTs). A total of 65 tumor samples from 63 patients diagnosed with typical parakeratinized cysts and KCOTs between 1992 and 2014 were retrospectively studied. Clinical and histopathological data and treatment modality were reviewed. In addition, the expression profiles of Ki-67, cluster of differentiation (CD)34 and podoplanin were assessed using immunohistochemistry. The association between these factors and the rate of KCOT recurrence was evaluated. The presence of daughter cysts, epithelial islands and high Ki-67, CD34 and podoplanin expression levels were revealed to be associated with tumor recurrence. In particular, univariate analysis revealed that high CD34 expression levels were significantly associated with tumor recurrence (P=0.034), as was conservative surgical treatment (P=0.003). Multivariate analysis revealed that conservative treatment was the greatest independent risk factor for tumor recurrence (odds ratio=13.337; P=0.018). These results suggest that overexpression of CD34 may be a potent predictor of tumor recurrence and radical treatment of the teeth that are in contact with the tumors is recommended in order to prevent tumor recurrence. D.A. Spandidos 2017-05 2017-03-24 /pmc/articles/PMC5431266/ /pubmed/28521454 http://dx.doi.org/10.3892/ol.2017.5905 Text en Copyright: © Naruse et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Naruse, Tomofumi
Yamashita, Kentaro
Yanamoto, Souichi
Rokutanda, Satoshi
Matsushita, Yuki
Sakamoto, Yuki
Sakamoto, Hiroshi
Ikeda, Hisazumi
Ikeda, Tohru
Asahina, Izumi
Umeda, Masahiro
Histopathological and immunohistochemical study in keratocystic odontogenic tumors: Predictive factors of recurrence
title Histopathological and immunohistochemical study in keratocystic odontogenic tumors: Predictive factors of recurrence
title_full Histopathological and immunohistochemical study in keratocystic odontogenic tumors: Predictive factors of recurrence
title_fullStr Histopathological and immunohistochemical study in keratocystic odontogenic tumors: Predictive factors of recurrence
title_full_unstemmed Histopathological and immunohistochemical study in keratocystic odontogenic tumors: Predictive factors of recurrence
title_short Histopathological and immunohistochemical study in keratocystic odontogenic tumors: Predictive factors of recurrence
title_sort histopathological and immunohistochemical study in keratocystic odontogenic tumors: predictive factors of recurrence
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431266/
https://www.ncbi.nlm.nih.gov/pubmed/28521454
http://dx.doi.org/10.3892/ol.2017.5905
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