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Dosimetric comparison of intensity-modulated radiation therapy and volumetric-modulated arc therapy plans for the treatment of glioma using flattening filter-free and flattening filter modes
In the present study, the dose verification between 6X and 6X flattening filter-free (FFF) in intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) was compared, and the advantages and disadvantages of different radiotherapy plans were evaluated. All four plans ach...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431317/ https://www.ncbi.nlm.nih.gov/pubmed/28521451 http://dx.doi.org/10.3892/ol.2017.5883 |
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author | Xu, Dandan Jia, Fei Li, Guowen Li, Hongfei |
author_facet | Xu, Dandan Jia, Fei Li, Guowen Li, Hongfei |
author_sort | Xu, Dandan |
collection | PubMed |
description | In the present study, the dose verification between 6X and 6X flattening filter-free (FFF) in intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) was compared, and the advantages and disadvantages of different radiotherapy plans were evaluated. All four plans achieved comparable heterogeneity and conformity indices. For frontal tumor, VMAT demonstrated more improved sparing of the brainstem compared with the IMRT (P=0.045); while in the model of FFF, the Dmax of eye lens was significantly reduced by 16–21% (P<0.001). The organs at risk (OARs) in the temporal lobe tumor were spared well in the IMRT plan. With the removal of FF, the low-dose volume for both tumor locations was significantly reduced (P<0.05). By contrast, there was no significant difference in monitor units (MUs) with FFF, but the MUs were significantly reduced in the VMAT plan (P<0.001). Regarding the protection of OARs, FFF appeared to be superior compared with FF. For the frontal glioma, the VMAT plan had more advantages, and for temporal lobe tumor, dynamic IMRT was more appropriate. The VMAT plan reduces the low-dose volume of normal brain tissues and the MUs. While the removal of FF may increase the dose rate, the shortened treatment delivery time may improve the accuracy of treatment due to intra-fractional patient motion. |
format | Online Article Text |
id | pubmed-5431317 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-54313172017-05-17 Dosimetric comparison of intensity-modulated radiation therapy and volumetric-modulated arc therapy plans for the treatment of glioma using flattening filter-free and flattening filter modes Xu, Dandan Jia, Fei Li, Guowen Li, Hongfei Oncol Lett Articles In the present study, the dose verification between 6X and 6X flattening filter-free (FFF) in intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) was compared, and the advantages and disadvantages of different radiotherapy plans were evaluated. All four plans achieved comparable heterogeneity and conformity indices. For frontal tumor, VMAT demonstrated more improved sparing of the brainstem compared with the IMRT (P=0.045); while in the model of FFF, the Dmax of eye lens was significantly reduced by 16–21% (P<0.001). The organs at risk (OARs) in the temporal lobe tumor were spared well in the IMRT plan. With the removal of FF, the low-dose volume for both tumor locations was significantly reduced (P<0.05). By contrast, there was no significant difference in monitor units (MUs) with FFF, but the MUs were significantly reduced in the VMAT plan (P<0.001). Regarding the protection of OARs, FFF appeared to be superior compared with FF. For the frontal glioma, the VMAT plan had more advantages, and for temporal lobe tumor, dynamic IMRT was more appropriate. The VMAT plan reduces the low-dose volume of normal brain tissues and the MUs. While the removal of FF may increase the dose rate, the shortened treatment delivery time may improve the accuracy of treatment due to intra-fractional patient motion. D.A. Spandidos 2017-05 2017-03-21 /pmc/articles/PMC5431317/ /pubmed/28521451 http://dx.doi.org/10.3892/ol.2017.5883 Text en Copyright: © Xu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Xu, Dandan Jia, Fei Li, Guowen Li, Hongfei Dosimetric comparison of intensity-modulated radiation therapy and volumetric-modulated arc therapy plans for the treatment of glioma using flattening filter-free and flattening filter modes |
title | Dosimetric comparison of intensity-modulated radiation therapy and volumetric-modulated arc therapy plans for the treatment of glioma using flattening filter-free and flattening filter modes |
title_full | Dosimetric comparison of intensity-modulated radiation therapy and volumetric-modulated arc therapy plans for the treatment of glioma using flattening filter-free and flattening filter modes |
title_fullStr | Dosimetric comparison of intensity-modulated radiation therapy and volumetric-modulated arc therapy plans for the treatment of glioma using flattening filter-free and flattening filter modes |
title_full_unstemmed | Dosimetric comparison of intensity-modulated radiation therapy and volumetric-modulated arc therapy plans for the treatment of glioma using flattening filter-free and flattening filter modes |
title_short | Dosimetric comparison of intensity-modulated radiation therapy and volumetric-modulated arc therapy plans for the treatment of glioma using flattening filter-free and flattening filter modes |
title_sort | dosimetric comparison of intensity-modulated radiation therapy and volumetric-modulated arc therapy plans for the treatment of glioma using flattening filter-free and flattening filter modes |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431317/ https://www.ncbi.nlm.nih.gov/pubmed/28521451 http://dx.doi.org/10.3892/ol.2017.5883 |
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