Crystal structure-based discovery of a novel synthesized PARP1 inhibitor (OL-1) with apoptosis-inducing mechanisms in triple-negative breast cancer

Poly (ADP-ribose) polymerase-1 (PARP1) is a highly conserved enzyme focused on the self-repair of cellular DNA damage. Until now, numbers of PARP inhibitors have been reported and used for breast cancer therapy in recent years, especially in TNBC. However, developing a new type PARP inhibitor with d...

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Detalles Bibliográficos
Autores principales: Fu, Leilei, Wang, Shuya, Wang, Xuan, Wang, Peiqi, Zheng, Yaxin, Yao, Dahong, Guo, Mingrui, Zhang, Lan, Ouyang, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431371/
https://www.ncbi.nlm.nih.gov/pubmed/28442756
http://dx.doi.org/10.1038/s41598-016-0007-2

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