Cargando…

Chemokine-like factor-like MARVEL transmembrane domain-containing 3 expression is associated with a favorable prognosis in esophageal squamous cell carcinoma

Decreased expression of human chemokine-like factor-like MARVEL transmembrane domain-containing 3 (CMTM3) has been identified in a number of human tumors and tumor cell lines, including gastric and testicular cancer, and PC3, CAL27 and Tca-83 cell lines. However, the association between CMTM3 expres...

Descripción completa

Detalles Bibliográficos
Autores principales: Han, Tianci, Shu, Tianci, Dong, Siyuan, Li, Peiwen, Li, Weinan, Liu, Dali, Qi, Ruiqun, Zhang, Shuguang, Zhang, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431419/
https://www.ncbi.nlm.nih.gov/pubmed/28521405
http://dx.doi.org/10.3892/ol.2017.5837
_version_ 1783236422211207168
author Han, Tianci
Shu, Tianci
Dong, Siyuan
Li, Peiwen
Li, Weinan
Liu, Dali
Qi, Ruiqun
Zhang, Shuguang
Zhang, Lin
author_facet Han, Tianci
Shu, Tianci
Dong, Siyuan
Li, Peiwen
Li, Weinan
Liu, Dali
Qi, Ruiqun
Zhang, Shuguang
Zhang, Lin
author_sort Han, Tianci
collection PubMed
description Decreased expression of human chemokine-like factor-like MARVEL transmembrane domain-containing 3 (CMTM3) has been identified in a number of human tumors and tumor cell lines, including gastric and testicular cancer, and PC3, CAL27 and Tca-83 cell lines. However, the association between CMTM3 expression and the clinicopathological features and prognosis of esophageal squamous cell carcinoma (ESCC) patients remains unclear. The aim of the present study was to investigate the correlation between CMTM3 expression and clinicopathological parameters and prognosis in ESCC. CMTM3 mRNA and protein expression was analyzed in ESCC and paired non-tumor tissues by quantitative real-time polymerase chain reaction, western blotting and immunohistochemical analysis. The Kaplan-Meier method was used to plot survival curves and the Cox proportional hazards regression model was also used for univariate and multivariate survival analysis. The results revealed that CMTM3 mRNA and protein expression levels were lower in 82.5% (30/40) and 75% (30/40) of ESCC tissues, respectively, when compared with matched non-tumor tissues. Statistical analysis demonstrated that CMTM3 expression was significantly correlated with lymph node metastasis (P=0.002) and clinical stage (P<0.001) in ESCC tissues. Furthermore, the survival time of ESCC patients exhibiting low CMTM3 expression was significantly shorter than that of ESCC patients exhibiting high CMTM3 expression (P=0.01). In addition, Kaplan-Meier survival analysis revealed that the overall survival time of patients exhibiting low CMTM3 expression was significantly decreased compared with patients exhibiting high CMTM3 expression (P=0.010). Cox multivariate analysis indicated that CMTM3 protein expression was an independent prognostic predictor for ESCC after resection. This study indicated that CMTM3 expression is significantly decreased in ESCC tissues and CMTM3 protein expression in resected tumors may present an effective prognostic biomarker.
format Online
Article
Text
id pubmed-5431419
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher D.A. Spandidos
record_format MEDLINE/PubMed
spelling pubmed-54314192017-05-17 Chemokine-like factor-like MARVEL transmembrane domain-containing 3 expression is associated with a favorable prognosis in esophageal squamous cell carcinoma Han, Tianci Shu, Tianci Dong, Siyuan Li, Peiwen Li, Weinan Liu, Dali Qi, Ruiqun Zhang, Shuguang Zhang, Lin Oncol Lett Articles Decreased expression of human chemokine-like factor-like MARVEL transmembrane domain-containing 3 (CMTM3) has been identified in a number of human tumors and tumor cell lines, including gastric and testicular cancer, and PC3, CAL27 and Tca-83 cell lines. However, the association between CMTM3 expression and the clinicopathological features and prognosis of esophageal squamous cell carcinoma (ESCC) patients remains unclear. The aim of the present study was to investigate the correlation between CMTM3 expression and clinicopathological parameters and prognosis in ESCC. CMTM3 mRNA and protein expression was analyzed in ESCC and paired non-tumor tissues by quantitative real-time polymerase chain reaction, western blotting and immunohistochemical analysis. The Kaplan-Meier method was used to plot survival curves and the Cox proportional hazards regression model was also used for univariate and multivariate survival analysis. The results revealed that CMTM3 mRNA and protein expression levels were lower in 82.5% (30/40) and 75% (30/40) of ESCC tissues, respectively, when compared with matched non-tumor tissues. Statistical analysis demonstrated that CMTM3 expression was significantly correlated with lymph node metastasis (P=0.002) and clinical stage (P<0.001) in ESCC tissues. Furthermore, the survival time of ESCC patients exhibiting low CMTM3 expression was significantly shorter than that of ESCC patients exhibiting high CMTM3 expression (P=0.01). In addition, Kaplan-Meier survival analysis revealed that the overall survival time of patients exhibiting low CMTM3 expression was significantly decreased compared with patients exhibiting high CMTM3 expression (P=0.010). Cox multivariate analysis indicated that CMTM3 protein expression was an independent prognostic predictor for ESCC after resection. This study indicated that CMTM3 expression is significantly decreased in ESCC tissues and CMTM3 protein expression in resected tumors may present an effective prognostic biomarker. D.A. Spandidos 2017-05 2017-03-10 /pmc/articles/PMC5431419/ /pubmed/28521405 http://dx.doi.org/10.3892/ol.2017.5837 Text en Copyright: © Han et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Han, Tianci
Shu, Tianci
Dong, Siyuan
Li, Peiwen
Li, Weinan
Liu, Dali
Qi, Ruiqun
Zhang, Shuguang
Zhang, Lin
Chemokine-like factor-like MARVEL transmembrane domain-containing 3 expression is associated with a favorable prognosis in esophageal squamous cell carcinoma
title Chemokine-like factor-like MARVEL transmembrane domain-containing 3 expression is associated with a favorable prognosis in esophageal squamous cell carcinoma
title_full Chemokine-like factor-like MARVEL transmembrane domain-containing 3 expression is associated with a favorable prognosis in esophageal squamous cell carcinoma
title_fullStr Chemokine-like factor-like MARVEL transmembrane domain-containing 3 expression is associated with a favorable prognosis in esophageal squamous cell carcinoma
title_full_unstemmed Chemokine-like factor-like MARVEL transmembrane domain-containing 3 expression is associated with a favorable prognosis in esophageal squamous cell carcinoma
title_short Chemokine-like factor-like MARVEL transmembrane domain-containing 3 expression is associated with a favorable prognosis in esophageal squamous cell carcinoma
title_sort chemokine-like factor-like marvel transmembrane domain-containing 3 expression is associated with a favorable prognosis in esophageal squamous cell carcinoma
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431419/
https://www.ncbi.nlm.nih.gov/pubmed/28521405
http://dx.doi.org/10.3892/ol.2017.5837
work_keys_str_mv AT hantianci chemokinelikefactorlikemarveltransmembranedomaincontaining3expressionisassociatedwithafavorableprognosisinesophagealsquamouscellcarcinoma
AT shutianci chemokinelikefactorlikemarveltransmembranedomaincontaining3expressionisassociatedwithafavorableprognosisinesophagealsquamouscellcarcinoma
AT dongsiyuan chemokinelikefactorlikemarveltransmembranedomaincontaining3expressionisassociatedwithafavorableprognosisinesophagealsquamouscellcarcinoma
AT lipeiwen chemokinelikefactorlikemarveltransmembranedomaincontaining3expressionisassociatedwithafavorableprognosisinesophagealsquamouscellcarcinoma
AT liweinan chemokinelikefactorlikemarveltransmembranedomaincontaining3expressionisassociatedwithafavorableprognosisinesophagealsquamouscellcarcinoma
AT liudali chemokinelikefactorlikemarveltransmembranedomaincontaining3expressionisassociatedwithafavorableprognosisinesophagealsquamouscellcarcinoma
AT qiruiqun chemokinelikefactorlikemarveltransmembranedomaincontaining3expressionisassociatedwithafavorableprognosisinesophagealsquamouscellcarcinoma
AT zhangshuguang chemokinelikefactorlikemarveltransmembranedomaincontaining3expressionisassociatedwithafavorableprognosisinesophagealsquamouscellcarcinoma
AT zhanglin chemokinelikefactorlikemarveltransmembranedomaincontaining3expressionisassociatedwithafavorableprognosisinesophagealsquamouscellcarcinoma