Engineered HSV vector achieves safe long-term transgene expression in the central nervous system

Previously we reported a new series of highly defective herpes simplex virus type 1 (HSV-1) vectors that were functionally devoid of all viral immediately early (IE) genes, resulting in virtual absence of viral gene expression. Nevertheless, a reporter gene cassette inserted into the vector flanked...

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Detalles Bibliográficos
Autores principales: Verlengia, Gianluca, Miyagawa, Yoshitaka, Ingusci, Selene, Cohen, Justus B., Simonato, Michele, Glorioso, Joseph C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431452/
https://www.ncbi.nlm.nih.gov/pubmed/28473703
http://dx.doi.org/10.1038/s41598-017-01635-1

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