Cargando…

Molecular mechanisms underlying the evolution of the slp76 signalosome

The well-defined mammalian slp76-signalosome is crucial for T-cell immune response, yet whether slp76-signalosome exists in invertebrates and how it evolved remain unknown. Here we investigated slp76-signalosome from an evolutionary perspective in amphioxus Branchiostoma belcheri (bb). We proved slp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qu, Xuemei, Lan, Xin, Deng, Chong, Zhou, Jiatao, Du, Jingjing, Huang, Shengfeng, Li, Yingqiu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431462/ https://www.ncbi.nlm.nih.gov/pubmed/28473706 http://dx.doi.org/10.1038/s41598-017-01660-0

Ejemplares similares

Identification and Characterization of the Amphioxus Lck and Its Associated Tyrosine Phosphorylation-Dependent Inhibitory LRR Receptor
por: Zhou, Jiatao, et al.
Publicado: (2021)

Identification of molecular glues of the SLP76/14-3-3 protein–protein interaction
por: Soini, Lorenzo, et al.
Publicado: (2021)

Cbl Enforces an SLP76-dependent Signaling Pathway for T Cell Differentiation
por: Chiang, Y. Jeffrey, et al.
Publicado: (2009)

Targeting adaptor protein SLP76 of RAGE as a therapeutic approach for lethal sepsis
por: Yan, Zhengzheng, et al.
Publicado: (2021)

Differential Requirement for LAT and SLP-76 in GPVI versus T Cell Receptor Signaling
por: Judd, Barbi A., et al.
Publicado: (2002)

Involvement of Lat, Gads, and Grb2 in Compartmentation of Slp-76 to the Plasma Membrane
por: Ishiai, Masamichi, et al.
Publicado: (2000)

Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo
por: Bezman, Natalie A., et al.
Publicado: (2008)

p95vav associates with tyrosine-phosphorylated SLP-76 in antigen- stimulated T cells
Publicado: (1996)

Conditional deletion reveals a cell-autonomous requirement of SLP-76 for thymocyte selection
por: Maltzman, Jonathan S., et al.
Publicado: (2005)

The adaptor molecules LAT and SLP-76 are specifically targeted by Yersinia to inhibit T cell activation
por: Gerke, Christiane, et al.
Publicado: (2005)

Serine Phosphorylation of SLP76 Is Dispensable for T Cell Development but Modulates Helper T Cell Function
por: Navas, Victor H., et al.
Publicado: (2017)

Targeting SLP76:ITK interaction separates GVHD from GVL in allo-HSCT
por: Mammadli, Mahinbanu, et al.
Publicado: (2021)

Investigation of Phospholipase Cγ1 Interaction with SLP76 Using Molecular Modeling Methods for Identifying Novel Inhibitors
por: Tripathi, Neha, et al.
Publicado: (2019)

Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury
por: Block, Helena, et al.
Publicado: (2012)

Quantitative Phosphoproteomics Reveals SLP-76 Dependent Regulation of PAG and Src Family Kinases in T Cells
por: Cao, Lulu, et al.
Publicado: (2012)

T cell specific adaptor protein (TSAd) promotes interaction of Nck with Lck and SLP-76 in T cells
por: Hem, Cecilie Dahl, et al.
Publicado: (2015)

T Cell Costimulation by CD6 Is Dependent on Bivalent Binding of a GADS/SLP-76 Complex
por: Breuning, Johannes, et al.
Publicado: (2017)

Inherited SLP76 deficiency in humans causes severe combined immunodeficiency, neutrophil and platelet defects
por: Lev, Atar, et al.
Publicado: (2020)

Structural Evolution of TIR-Domain Signalosomes
por: Nimma, Surekha, et al.
Publicado: (2021)

Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production
Publicado: (1996)

Inactivation of c-Cbl Reverses Neonatal Lethality and T Cell Developmental Arrest of SLP-76–deficient Mice
por: Chiang, Y. Jeffrey, et al.
Publicado: (2004)

Clnk, a Novel Slp-76–Related Adaptor Molecule Expressed in Cytokine-Stimulated Hemopoietic Cells
por: Cao, Ming Yu, et al.
Publicado: (1999)

Differential Requirements for Src-Family Kinases in SYK or ZAP70-Mediated SLP-76 Phosphorylation in Lymphocytes
por: Fasbender, Frank, et al.
Publicado: (2017)

Mapping the SLP76 interactome in T cells lacking each of the GRB2-family adaptors reveals molecular plasticity of the TCR signaling pathway
por: Ruminski, Kilian, et al.
Publicado: (2023)

ADAP–SLP-76 Binding Differentially Regulates Supramolecular Activation Cluster (SMAC) Formation Relative to T Cell–APC Conjugation
por: Wang, Hongyan, et al.
Publicado: (2004)

The Evolution of COP9 Signalosome in Unicellular and Multicellular Organisms
por: Barth, Emanuel, et al.
Publicado: (2016)

Expression and clinical significance of SLP-2 in ovarian tumors
por: Zhang, Jingjing, et al.
Publicado: (2019)

Recruitment of Slp-76 to the Membrane and Glycolipid-Enriched Membrane Microdomains Replaces the Requirement for Linker for Activation of T Cells in T Cell Receptor Signaling
por: Boerth, Nancy J., et al.
Publicado: (2000)

Grf40, A Novel Grb2 Family Member, Is Involved in T Cell Signaling through Interaction with SLP-76 and LAT
por: Asada, Hiroshi, et al.
Publicado: (1999)

GrpL, a Grb2-related Adaptor Protein, Interacts with SLP-76 to Regulate Nuclear Factor of Activated T Cell Activation
por: Law, Che-Leung, et al.
Publicado: (1999)

Hematopoietic cell phosphatase, SHP-1, is constitutively associated with the SH2 domain-containing leukocyte protein, SLP-76, in B cells
Publicado: (1996)

Allelic Exclusion of the T Cell Receptor β Locus Requires the Sh2 Domain–Containing Leukocyte Protein (Slp)-76 Adaptor Protein
por: Aifantis, Iannis, et al.
Publicado: (1999)

SLP-76 Sterile α Motif (SAM) and Individual H5 α Helix Mediate Oligomer Formation for Microclusters and T-cell Activation
por: Liu, Hebin, et al.
Publicado: (2013)

A novel pathway down-modulating T cell activation involves HPK-1–dependent recruitment of 14-3-3 proteins on SLP-76
por: Bartolo, Vincenzo Di, et al.
Publicado: (2007)

Positive and negative regulation by SLP-76/ADAP and Pyk2 of chemokine-stimulated T-lymphocyte adhesion mediated by integrin α4β1
por: Dios-Esponera, Ana, et al.
Publicado: (2015)

The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells
por: Liu, Hebin, et al.
Publicado: (2015)

Slp1 and Slp2-a Localize to the Plasma Membrane of CTL and Contribute to Secretion from the Immunological Synapse
por: Holt, Oliver, et al.
Publicado: (2008)

Targeting the COP9 signalosome for cancer therapy
por: Du, Wenqi, et al.
Publicado: (2022)

AKT2 deficiency impairs formation of the BCR signalosome
por: Du, Zuochen, et al.
Publicado: (2020)

Activated Cdc42-associated kinase 1 (ACK1) binds the sterile α motif (SAM) domain of the adaptor SLP-76 and phosphorylates proximal tyrosines
por: Thaker, Youg R., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_t1e9ranb9cjvs2ui69u7eforvc