Role of Akt-independent mTORC1 and GSK3β signaling in sublethal NMDA-induced injury and the recovery of neuronal electrophysiology and survival

Glutamate-induced excitotoxicity, mediated by overstimulation of N-methyl-D-aspartate (NMDA) receptors, is a mechanism that causes secondary damage to neurons. The early phase of injury causes loss of dendritic spines and changes to synaptic activity. The phosphatidylinositol-4,5-bisphosphate 3-kina...

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Detalles Bibliográficos
Autores principales: Swiatkowski, Przemyslaw, Nikolaeva, Ina, Kumar, Gaurav, Zucco, Avery, Akum, Barbara F., Patel, Mihir V., D’Arcangelo, Gabriella, Firestein, Bonnie L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431483/
https://www.ncbi.nlm.nih.gov/pubmed/28484273
http://dx.doi.org/10.1038/s41598-017-01826-w

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