A molecular beacon-based approach for live-cell imaging of RNA transcripts with minimal target engineering at the single-molecule level

Analysis of RNA dynamics and localization at the single-molecule level in living cells has been predominantly achieved by engineering target RNAs with large insertions of tandem repeat sequences that are bound by protein-based or oligonucleotide-based fluorescent probes. Thus, individual RNAs are ta...

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Detalles Bibliográficos
Autores principales: Chen, Mingming, Ma, Zhao, Wu, Xiaotian, Mao, Shiqi, Yang, Yantao, Tan, Jie, Krueger, Christopher J., Chen, Antony K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431543/
https://www.ncbi.nlm.nih.gov/pubmed/28484218
http://dx.doi.org/10.1038/s41598-017-01740-1

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