Regulation of CHK1 by mTOR contributes to the evasion of DNA damage barrier of cancer cells

Oncogenic transformation leads to dysregulated cell proliferation, nutrient deficiency, and hypoxia resulting in metabolic stress and increased DNA damage. In normal cells, such metabolic stress leads to inhibition of signaling through the mammalian Target of Rapamycin Complex 1 (mTORC1), reduction...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Xinhui, Liu, Weijin, Hu, Xing, Dorrance, Adrienne, Garzon, Ramiro, Houghton, Peter J., Shen, Changxian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431544/
https://www.ncbi.nlm.nih.gov/pubmed/28484242
http://dx.doi.org/10.1038/s41598-017-01729-w

Ejemplares similares

Ejemplares similares