Suppression of autoimmune demyelinating disease by preferential stimulation of CNS-specific CD8 T cells using Listeria-encoded neuroantigen

CD8 T-cells predominate in CNS lesions of MS patients and display oligoclonal expansion. However, the role of myelin-specific CD8 T-cells in disease remains unclear, with studies showing protective and pathogenic roles in EAE. We demonstrated a disease-suppressive function for CNS-specific CD8 T-cel...

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Detalles Bibliográficos
Autores principales: Itani, Farah R., Sinha, Sushmita, Brate, Ashley A., Pewe, Lecia L., Gibson-Corley, Katherine N., Harty, John T., Karandikar, Nitin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431563/
https://www.ncbi.nlm.nih.gov/pubmed/28484224
http://dx.doi.org/10.1038/s41598-017-01771-8

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