Cargando…
Pazopanib-induced asymptomatic radiological acute pancreatitis: A case report
The universal clinical use of multi-targeted tyrosine kinase inhibitors (TKIs) in patients diagnosed with advanced renal cell carcinoma (RCC) has significantly prolonged their estimated survival times and their quality of life. However, several adverse side-effects associated predominantly with the...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431634/ https://www.ncbi.nlm.nih.gov/pubmed/28529741 http://dx.doi.org/10.3892/mco.2017.1210 |
_version_ | 1783236463559704576 |
---|---|
author | Baraibar, Iosune Quílez, Almudena Salas, Diego Román, Marta Rolfo, Christian Pérez-Gracia, José L. Gil-Bazo, Ignacio |
author_facet | Baraibar, Iosune Quílez, Almudena Salas, Diego Román, Marta Rolfo, Christian Pérez-Gracia, José L. Gil-Bazo, Ignacio |
author_sort | Baraibar, Iosune |
collection | PubMed |
description | The universal clinical use of multi-targeted tyrosine kinase inhibitors (TKIs) in patients diagnosed with advanced renal cell carcinoma (RCC) has significantly prolonged their estimated survival times and their quality of life. However, several adverse side-effects associated predominantly with the inhibition of the vascular endothelial growth factor receptor by these drugs may prove to be potentially life-threatening. One adverse event that is only rarely observed with the use of TKIs in this clinical setting is acute pancreatitis. In the present study, to the best of our knowledge, the first case of asymptomatic radiological acute pancreatitis associated with the use of pazopanib in monotherapy in a patient with RCC is presented. In addition, a comprehensive review of the literature on this topic is provided, and certain potential measures that may aid in early diagnosis and treatment are discussed. |
format | Online Article Text |
id | pubmed-5431634 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-54316342017-05-19 Pazopanib-induced asymptomatic radiological acute pancreatitis: A case report Baraibar, Iosune Quílez, Almudena Salas, Diego Román, Marta Rolfo, Christian Pérez-Gracia, José L. Gil-Bazo, Ignacio Mol Clin Oncol Articles The universal clinical use of multi-targeted tyrosine kinase inhibitors (TKIs) in patients diagnosed with advanced renal cell carcinoma (RCC) has significantly prolonged their estimated survival times and their quality of life. However, several adverse side-effects associated predominantly with the inhibition of the vascular endothelial growth factor receptor by these drugs may prove to be potentially life-threatening. One adverse event that is only rarely observed with the use of TKIs in this clinical setting is acute pancreatitis. In the present study, to the best of our knowledge, the first case of asymptomatic radiological acute pancreatitis associated with the use of pazopanib in monotherapy in a patient with RCC is presented. In addition, a comprehensive review of the literature on this topic is provided, and certain potential measures that may aid in early diagnosis and treatment are discussed. D.A. Spandidos 2017-05 2017-04-06 /pmc/articles/PMC5431634/ /pubmed/28529741 http://dx.doi.org/10.3892/mco.2017.1210 Text en Copyright: © Baraibar et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Baraibar, Iosune Quílez, Almudena Salas, Diego Román, Marta Rolfo, Christian Pérez-Gracia, José L. Gil-Bazo, Ignacio Pazopanib-induced asymptomatic radiological acute pancreatitis: A case report |
title | Pazopanib-induced asymptomatic radiological acute pancreatitis: A case report |
title_full | Pazopanib-induced asymptomatic radiological acute pancreatitis: A case report |
title_fullStr | Pazopanib-induced asymptomatic radiological acute pancreatitis: A case report |
title_full_unstemmed | Pazopanib-induced asymptomatic radiological acute pancreatitis: A case report |
title_short | Pazopanib-induced asymptomatic radiological acute pancreatitis: A case report |
title_sort | pazopanib-induced asymptomatic radiological acute pancreatitis: a case report |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431634/ https://www.ncbi.nlm.nih.gov/pubmed/28529741 http://dx.doi.org/10.3892/mco.2017.1210 |
work_keys_str_mv | AT baraibariosune pazopanibinducedasymptomaticradiologicalacutepancreatitisacasereport AT quilezalmudena pazopanibinducedasymptomaticradiologicalacutepancreatitisacasereport AT salasdiego pazopanibinducedasymptomaticradiologicalacutepancreatitisacasereport AT romanmarta pazopanibinducedasymptomaticradiologicalacutepancreatitisacasereport AT rolfochristian pazopanibinducedasymptomaticradiologicalacutepancreatitisacasereport AT perezgraciajosel pazopanibinducedasymptomaticradiologicalacutepancreatitisacasereport AT gilbazoignacio pazopanibinducedasymptomaticradiologicalacutepancreatitisacasereport |