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Ruanjian Sanjie decoction exhibits antitumor activity by inducing cell apoptosis in breast cancer
Traditional Chinese medicine, based on theories developed and practiced for >2,000 years, is one of the most common complementary and alternative types of medicine currently used in the treatment of patients with breast cancer. Ruanjian Sanjie (RJSJ) decoction, is composed of four herbs, includin...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431657/ https://www.ncbi.nlm.nih.gov/pubmed/28529560 http://dx.doi.org/10.3892/ol.2017.5832 |
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author | Zhao, Xiumei Zhao, Jing Hu, Renjie Yao, Qiang Zhang, Guixian Shen, Hongsheng Yagüe, Ernesto Hu, Yunhui |
author_facet | Zhao, Xiumei Zhao, Jing Hu, Renjie Yao, Qiang Zhang, Guixian Shen, Hongsheng Yagüe, Ernesto Hu, Yunhui |
author_sort | Zhao, Xiumei |
collection | PubMed |
description | Traditional Chinese medicine, based on theories developed and practiced for >2,000 years, is one of the most common complementary and alternative types of medicine currently used in the treatment of patients with breast cancer. Ruanjian Sanjie (RJSJ) decoction, is composed of four herbs, including Ban xia (Pinellia ternata), Xia ku cao (Prunella vulgaris), Shan ci gu (Cremastra appendiculata) and Hai zao (Sargassum pallidum), and has traditionally been used for softening hard lumps and resolving hard tissue masses. However, the active compounds and mechanisms of action of RJSJ remain unknown. The present study demonstrated the antitumor activity of RJSJ against Ehrlich ascites carcinoma in Swiss albino mice and breast cancer xenografts in nude mice. Notably, RJSJ does not induce body weight loss, immune function toxicity or myelosuppression in mice, indicating that it is safe and well tolerated. In addition, RJSJ shows potent cytotoxicity against breast cancer cells in vitro by the suppression of the anti-apoptotic proteins B-cell lymphoma 2 and survivin, leading to the activation of caspase-3/7 and caspase-9, and the apoptotic cascade. These findings provide a clear rationale to explore the therapeutic strategy of using RJSJ alone or in combination with chemotherapeutic agents for breast cancer patients and the characterization of its active principles. |
format | Online Article Text |
id | pubmed-5431657 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-54316572017-05-19 Ruanjian Sanjie decoction exhibits antitumor activity by inducing cell apoptosis in breast cancer Zhao, Xiumei Zhao, Jing Hu, Renjie Yao, Qiang Zhang, Guixian Shen, Hongsheng Yagüe, Ernesto Hu, Yunhui Oncol Lett Articles Traditional Chinese medicine, based on theories developed and practiced for >2,000 years, is one of the most common complementary and alternative types of medicine currently used in the treatment of patients with breast cancer. Ruanjian Sanjie (RJSJ) decoction, is composed of four herbs, including Ban xia (Pinellia ternata), Xia ku cao (Prunella vulgaris), Shan ci gu (Cremastra appendiculata) and Hai zao (Sargassum pallidum), and has traditionally been used for softening hard lumps and resolving hard tissue masses. However, the active compounds and mechanisms of action of RJSJ remain unknown. The present study demonstrated the antitumor activity of RJSJ against Ehrlich ascites carcinoma in Swiss albino mice and breast cancer xenografts in nude mice. Notably, RJSJ does not induce body weight loss, immune function toxicity or myelosuppression in mice, indicating that it is safe and well tolerated. In addition, RJSJ shows potent cytotoxicity against breast cancer cells in vitro by the suppression of the anti-apoptotic proteins B-cell lymphoma 2 and survivin, leading to the activation of caspase-3/7 and caspase-9, and the apoptotic cascade. These findings provide a clear rationale to explore the therapeutic strategy of using RJSJ alone or in combination with chemotherapeutic agents for breast cancer patients and the characterization of its active principles. D.A. Spandidos 2017-05 2017-03-08 /pmc/articles/PMC5431657/ /pubmed/28529560 http://dx.doi.org/10.3892/ol.2017.5832 Text en Copyright: © Zhao et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Zhao, Xiumei Zhao, Jing Hu, Renjie Yao, Qiang Zhang, Guixian Shen, Hongsheng Yagüe, Ernesto Hu, Yunhui Ruanjian Sanjie decoction exhibits antitumor activity by inducing cell apoptosis in breast cancer |
title | Ruanjian Sanjie decoction exhibits antitumor activity by inducing cell apoptosis in breast cancer |
title_full | Ruanjian Sanjie decoction exhibits antitumor activity by inducing cell apoptosis in breast cancer |
title_fullStr | Ruanjian Sanjie decoction exhibits antitumor activity by inducing cell apoptosis in breast cancer |
title_full_unstemmed | Ruanjian Sanjie decoction exhibits antitumor activity by inducing cell apoptosis in breast cancer |
title_short | Ruanjian Sanjie decoction exhibits antitumor activity by inducing cell apoptosis in breast cancer |
title_sort | ruanjian sanjie decoction exhibits antitumor activity by inducing cell apoptosis in breast cancer |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431657/ https://www.ncbi.nlm.nih.gov/pubmed/28529560 http://dx.doi.org/10.3892/ol.2017.5832 |
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