The invasive Neisseria meningitidis MenC CC103 from Brazil is characterized by an accessory gene repertoire

Neisseria meningitidis infections are a major issue for global health. The invasive MenC ST-103 clonal complex (CC103) has been the most prevalent in meningococcal outbreaks in Brazil, occurring also in several countries worldwide. Here we have analysed the population structure and accessory genome...

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Autores principales: Marin, Michel Abanto, Fonseca, Erica, Encinas, Fernando, Freitas, Fernanda, Camargo, Dhian Almeida, Coimbra, Roney Santos, de Filippis, Ivano, Vicente, Ana Carolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431661/
https://www.ncbi.nlm.nih.gov/pubmed/28487566
http://dx.doi.org/10.1038/s41598-017-01671-x
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author Marin, Michel Abanto
Fonseca, Erica
Encinas, Fernando
Freitas, Fernanda
Camargo, Dhian Almeida
Coimbra, Roney Santos
de Filippis, Ivano
Vicente, Ana Carolina
author_facet Marin, Michel Abanto
Fonseca, Erica
Encinas, Fernando
Freitas, Fernanda
Camargo, Dhian Almeida
Coimbra, Roney Santos
de Filippis, Ivano
Vicente, Ana Carolina
author_sort Marin, Michel Abanto
collection PubMed
description Neisseria meningitidis infections are a major issue for global health. The invasive MenC ST-103 clonal complex (CC103) has been the most prevalent in meningococcal outbreaks in Brazil, occurring also in several countries worldwide. Here we have analysed the population structure and accessory genome of MenC CC103 strains from a global perspective. An in-depth phylogenomic analysis revealed a lineage of N. meningitidis causing meningitis in Brazil and the United Kingdom. This lineage was also characterized as harbouring a particular accessory genome composed of CRISPR/Cas and restriction modification systems. This lineage was also characterized by a genomic island resembling an integrative and conjugative element. This island carried genes potentially associated with virulence and fitness. We propose this accessory gene repertoire could be contributing to the spatial-temporal persistence of the invasive MenC CC103 lineage.
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spelling pubmed-54316612017-05-16 The invasive Neisseria meningitidis MenC CC103 from Brazil is characterized by an accessory gene repertoire Marin, Michel Abanto Fonseca, Erica Encinas, Fernando Freitas, Fernanda Camargo, Dhian Almeida Coimbra, Roney Santos de Filippis, Ivano Vicente, Ana Carolina Sci Rep Article Neisseria meningitidis infections are a major issue for global health. The invasive MenC ST-103 clonal complex (CC103) has been the most prevalent in meningococcal outbreaks in Brazil, occurring also in several countries worldwide. Here we have analysed the population structure and accessory genome of MenC CC103 strains from a global perspective. An in-depth phylogenomic analysis revealed a lineage of N. meningitidis causing meningitis in Brazil and the United Kingdom. This lineage was also characterized as harbouring a particular accessory genome composed of CRISPR/Cas and restriction modification systems. This lineage was also characterized by a genomic island resembling an integrative and conjugative element. This island carried genes potentially associated with virulence and fitness. We propose this accessory gene repertoire could be contributing to the spatial-temporal persistence of the invasive MenC CC103 lineage. Nature Publishing Group UK 2017-05-09 /pmc/articles/PMC5431661/ /pubmed/28487566 http://dx.doi.org/10.1038/s41598-017-01671-x Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Marin, Michel Abanto
Fonseca, Erica
Encinas, Fernando
Freitas, Fernanda
Camargo, Dhian Almeida
Coimbra, Roney Santos
de Filippis, Ivano
Vicente, Ana Carolina
The invasive Neisseria meningitidis MenC CC103 from Brazil is characterized by an accessory gene repertoire
title The invasive Neisseria meningitidis MenC CC103 from Brazil is characterized by an accessory gene repertoire
title_full The invasive Neisseria meningitidis MenC CC103 from Brazil is characterized by an accessory gene repertoire
title_fullStr The invasive Neisseria meningitidis MenC CC103 from Brazil is characterized by an accessory gene repertoire
title_full_unstemmed The invasive Neisseria meningitidis MenC CC103 from Brazil is characterized by an accessory gene repertoire
title_short The invasive Neisseria meningitidis MenC CC103 from Brazil is characterized by an accessory gene repertoire
title_sort invasive neisseria meningitidis menc cc103 from brazil is characterized by an accessory gene repertoire
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431661/
https://www.ncbi.nlm.nih.gov/pubmed/28487566
http://dx.doi.org/10.1038/s41598-017-01671-x
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