Altered balance of excitatory and inhibitory learning in a genetically modified mouse model of glutamatergic dysfunction relevant to schizophrenia

The GluA1 AMPAR subunit (encoded by the Gria1 gene) has been implicated in schizophrenia. Gria1 knockout in mice results in recently experienced stimuli acquiring aberrantly high salience. This suggests that GluA1 may be important for learning that is sensitive to the temporal contiguity between eve...

Descripción completa

Detalles Bibliográficos
Autores principales: Sanderson, David J., Lee, Aletheia, Sprengel, Rolf, Seeburg, Peter H., Harrison, Paul J., Bannerman, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431791/
https://www.ncbi.nlm.nih.gov/pubmed/28496171
http://dx.doi.org/10.1038/s41598-017-01925-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431791/
https://www.ncbi.nlm.nih.gov/pubmed/28496171
http://dx.doi.org/10.1038/s41598-017-01925-8

Ejemplares similares