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Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome

Dravet syndrome, an epileptic encephalopathy affecting children, largely results from heterozygous loss-of-function mutations in the brain voltage-gated sodium channel gene SCN1A. Heterozygous Scn1a knockout (Scn1a (+/−)) mice recapitulate the severe epilepsy phenotype of Dravet syndrome and are an...

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Detalles Bibliográficos
Autores principales:	Anderson, Lyndsey L., Hawkins, Nicole A., Thompson, Christopher H., Kearney, Jennifer A., George, Alfred L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431801/ https://www.ncbi.nlm.nih.gov/pubmed/28490751 http://dx.doi.org/10.1038/s41598-017-01851-9

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