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Transcriptome analysis of dominant-negative Brd4 mutants identifies Brd4-specific target genes of small molecule inhibitor JQ1

The bromodomain protein Brd4 is an epigenetic reader and plays a critical role in the development and maintenance of leukemia. Brd4 binds to acetylated histone tails and activates transcription by recruiting the positive elongation factor P-TEFb. Small molecule inhibitor JQ1 competitively binds the...

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Detalles Bibliográficos
Autores principales:	Decker, Tim-Michael, Kluge, Michael, Krebs, Stefan, Shah, Nilay, Blum, Helmut, Friedel, Caroline C., Eick, Dirk
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431861/ https://www.ncbi.nlm.nih.gov/pubmed/28490802 http://dx.doi.org/10.1038/s41598-017-01943-6

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