In situ click chemistry generation of cyclooxygenase-2 inhibitors

Cyclooxygenase-2 isozyme is a promising anti-inflammatory drug target, and overexpression of this enzyme is also associated with several cancers and neurodegenerative diseases. The amino-acid sequence and structural similarity between inducible cyclooxygenase-2 and housekeeping cyclooxygenase-1 isof...

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Detalles Bibliográficos
Autores principales: Bhardwaj, Atul, Kaur, Jatinder, Wuest, Melinda, Wuest, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431875/
https://www.ncbi.nlm.nih.gov/pubmed/28232747
http://dx.doi.org/10.1038/s41467-016-0009-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431875/
https://www.ncbi.nlm.nih.gov/pubmed/28232747
http://dx.doi.org/10.1038/s41467-016-0009-6

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