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In situ click chemistry generation of cyclooxygenase-2 inhibitors
Cyclooxygenase-2 isozyme is a promising anti-inflammatory drug target, and overexpression of this enzyme is also associated with several cancers and neurodegenerative diseases. The amino-acid sequence and structural similarity between inducible cyclooxygenase-2 and housekeeping cyclooxygenase-1 isof...
Autores principales: | Bhardwaj, Atul, Kaur, Jatinder, Wuest, Melinda, Wuest, Frank |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431875/ https://www.ncbi.nlm.nih.gov/pubmed/28232747 http://dx.doi.org/10.1038/s41467-016-0009-6 |
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