Zeylenone, a naturally occurring cyclohexene oxide, inhibits proliferation and induces apoptosis in cervical carcinoma cells via PI3K/AKT/mTOR and MAPK/ERK pathways

There is a strong rationale to therapeutically target the PI3K/Akt/mTOR and MAPK/ERK pathways in cervical carcinoma since they are highly deregulated in this disease. Previous study by our group have demonstrated that Zeylenone (Zey) exhibited strong suppressive activity on PI3K/AKT/mTOR and MAPK/ER...

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Detalles Bibliográficos
Autores principales: Zhang, Leilei, Huo, Xiaowei, Liao, Yonghong, Yang, Feifei, Gao, Li, Cao, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431878/
https://www.ncbi.nlm.nih.gov/pubmed/28490807
http://dx.doi.org/10.1038/s41598-017-01804-2

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