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Pharmacometabolomics for predicting variable busulfan exposure in paediatric haematopoietic stem cell transplantation patients

Owing to its narrow therapeutic range and high pharmacokinetic variability, optimal dosing for busulfan is important to minimise overexposure-related systemic toxicity and underexposure-related graft failure. Using global metabolomics, we investigated biomarkers for predicting busulfan exposure. We...

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Detalles Bibliográficos
Autores principales:	Kim, Bora, Lee, Ji Won, Hong, Kyung Taek, Yu, Kyung-Sang, Jang, In-Jin, Park, Kyung Duk, Shin, Hee Young, Ahn, Hyo Seop, Cho, Joo-Youn, Kang, Hyoung Jin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431879/ https://www.ncbi.nlm.nih.gov/pubmed/28490733 http://dx.doi.org/10.1038/s41598-017-01861-7

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